Trial reportNature2025
Closed-loop vagus nerve stimulation aids recovery from spinal cord injury.
Trial report in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07689227 (Early Feasibility Study of the ReWire System for Closed-Loop Vagus Nerve Stimulation), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Feasibility Study of the ReWire System for Closed-Loop Vagus Nerve Stimulation (CLV) Paired With Rehabilitation After Spinal Cord Injury (SCI) - Lower Limb Study
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of transcutaneous auricular vagus nerve stimulation in stroke rehabilitation: a systematic review and meta-analysis of randomized clinical trials.Frontiers in neurologyPooled it
- Safety and feasibility of paired vagus nerve stimulation with rehabilitation for improving upper extremity function in people with cervical spinal cord injury: a pilot randomized controlled trial.Frontiers in rehabilitation sciences · 2026Trial
- Trial
- Spatiotemporal disarray of inflammatory microenvironment following spinal cord injury.Neural regeneration research · 2026Article
- Neonatal small extracellular vesicle-loaded GelNB hydrogel reprograms the vascular-immune microenvironment for spinal cord injury repair.Bioactive materials · 2026Article
- Beyond Scar Removal: Reprogramming the Glial Scar for Neural Repair.International journal of molecular sciences · 2026Review
- Clinical trial landscape of cell therapy for spinal cord injury: from integrated practices to future developments.BMC medicine · 2026Article
- Good vibrations: Sternal vibration enhances white matter density and interoceptive awareness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Auricular Vagus Nerve Stimulation Combined with Physical Therapy for Individuals with Parkinson's Disease: A Pilot Randomized Sham-Controlled Trial.Neurology international · 2026Article
- Tissue-bioelectronics interfaces.Chemical Society reviews · 2026Review
- Closed-loop movement-paired transcutaneous auricular vagus nerve stimulation for upper-limb rehabilitation: a feasibility study.Journal of neuroengineering and rehabilitation · 2026Article
- Study design considerations in clinical trials testing transcutaneous stimulation for spinal cord injury.Spinal cord · 2026Review
- Rehabilitation paired with vagus nerve stimulation for motor function of chronic ischemic stroke patients in China: Study protocol of a multicenter randomized controlled trial (Repair Study).Neuroprotection (Chichester, England) · 2026Article
- Magnetically Responsive Piezoelectric Nanocapacitors Enhance Neural Recovery Following Spinal Cord Injury via Targeted Spinal Magnetic Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neuro-Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- Optoelectronic Interfaces for Nongenetic Modulation of Excitable Tissues.Small methods · 2026Review
- Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- The Interplay Between Neuromodulation and Stem Cell Therapy for Sensory-Motor Neuroplasticity After Spinal Cord Injury: A Perspective View.Journal of clinical medicine · 2026Article
- A structured narrative review on VNS-treated drug-resistant epilepsy: EEG markers, neurochemical mechanisms, and future biomarker-driven computational directions.Frontiers in neuroscience · 2026Review
- Single-Electrode, Bidirectional Control of Heart Rate via Vagus Nerve Modulation in Rat Model.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decades of research have demonstrated that recovery from serious neurological injury will require synergistic therapeutic approaches. Rewiring spared neural circuits after injury is a long-standing goal of neurorehabilitation
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.