Evidence map›Paper›PMID 40399642›Full record

ArticleCommunications biology2025

Neurogenetic phenotypes of learning-dependent plasticity for improved perceptual decisions.

Liz Yuanxi Lee, Joseph J Ziminski, Polytimi Frangou, Vasilis M Karlaftis, Yezhou Wang, Boris Bernhardt, Varun Warrier, Richard A I Bethlehem, Zoe Kourtzi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liz Yuanxi LeeDepartment of Psychology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6643-6312
Joseph J ZiminskiDepartment of Psychology, University of Cambridge, Cambridge, UK.
Polytimi FrangouDepartment of Psychology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3524-0306
Vasilis M KarlaftisDepartment of Psychology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1285-1593
Yezhou WangMcConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-3650-5476
Boris BernhardtMcConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-9256-6041
Varun WarrierDepartment of Psychology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-4532-8571
Richard A I BethlehemDepartment of Psychology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0714-0685
Zoe KourtziDepartment of Psychology, University of Cambridge, Cambridge, UK. zk240@cam.ac.uk.ORCID http://orcid.org/0000-0001-9441-7832

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) H012508, BB/P021255/1Wellcome Trust 223131Wellcome Trust (Wellcome) 205067/Z/16/Z; 223131/Z/21/Z
6 · The paper itself

Abstract

Genetics and experience are known to mold our cognitive development. Yet, the interactions between genetics and brain mechanisms that support learning and flexible behavior in the adult human brain remain largely unknown. Here, we test the link between brain-wide gene expression and macroscopic neuroimaging phenotypes of brain plasticity that support our ability to improve perceptual decisions with training. We demonstrate that gene expression links to learning-dependent changes in spatial variations of cortical microstructure and functional connectivity in visual and fronto-parietal networks that are known to be involved in perceptual decisions. Further, we show that brain stimulation in visual cortex during training boosts learning and alters functional connections, rather than microstructure organization, within and between these networks. Our results reveal neurogenetic phenotypes of plasticity in perceptual decision networks, providing insights into the interplay of genetic expression and macroscopic mechanisms of structural and functional plasticity for learning and flexible behavior.

Indexed as

BrainDecision MakingLearningNeuronal PlasticityAdultFemaleHumansMagnetic Resonance ImagingMalePhenotypeVisual CortexYoung Adult

Identifiers

PMID40399642
PMCPMC12095785

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.