Evidence map›Paper›PMID 40399636›Full record

ArticleMolecular and cellular biochemistry2025

Anti-inflammatory effects and gut microbiota modulation of synbiotic mulberry in DSS-induced colitis rats.

Atcharaporn Ontawong, Arthid Thim-Uam, Sirinat Pengnet, Narongsuk Munkong, Pairote Wongputtisin, Kullanat Kuntakhut, Prathakphong Riyamongkhol, Dej Mann, Doungporn Amornlerdpison

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Article in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Atcharaporn OntawongDivision of Physiology, School of Medical Sciences, University of Phayao, Phayao, 56000, Thailand.
Arthid Thim-UamDivision of Biochemistry, School of Medical Sciences, University of Phayao, Phayao, 56000, Thailand.
Sirinat PengnetDivision of Physiology, School of Medical Sciences, University of Phayao, Phayao, 56000, Thailand.
Narongsuk MunkongDepartment of Pathology, School of Medicine, University of Phayao, Phayao, 56000, Thailand.
Pairote WongputtisinProgram in Biotechnology, Faculty of Science, Maejo University, Chiang Mai, 50290, Thailand.
Kullanat KuntakhutCenter of Excellence in Agricultural Innovation for Graduate Entrepreneur, Maejo University, Chiang Mai, 50290, Thailand.
Prathakphong RiyamongkholLaboratory Animal Research Center, University of Phayao, Phayao, 56000, Thailand.
Dej MannLaboratory Animal Research Center, University of Phayao, Phayao, 56000, Thailand.
Doungporn AmornlerdpisonCenter of Excellence in Agricultural Innovation for Graduate Entrepreneur, Maejo University, Chiang Mai, 50290, Thailand. doungporn_a@mju.ac.th.

Funding

Technology and Innovation-Based Enterprise Development Fund YP 043/2565
6 · The paper itself

Abstract

The global incident shows that the number of inflammatory bowel disease (IBD) cases increased by 88.30% in 2021 and significantly influenced patients' quality of life. Synbiotics are recommended as an alternative or supplement for IBD. We formulated synbiotic mulberry (SM) by mixing mulberry powder, probiotic biomass, and inulin. However, the anti-inflammatory effect of SM and gut microbiota modulation in dextran-sodium-sulfate (DSS)-induced colitis rats has not been thoroughly investigated. Thus, the anti-inflammatory activity of SM and gut microbiota composition was explored using DSS-induced acute colitis rats. Rats were divided into seven groups: control, control+SM1000, DSS, DSS+SM250, DSS+SM500, DSS+SM1000, and DSS+Sulfazalazine (SUL). All DSS induction rats received dissolving 4% (w/v) DSS in drinking water for 7 days, and their respective treatment was once daily via oral gavage. In addition, DSS-aggravated colitis rats received 0.4% (w/v) DSS in drinking water and their respective treatments once daily for the next 7 days. SM improved the disease activity index (DAI), body weight (BW), hepatosplenomegaly, colon length, and colon histomorphology, with outcomes similar to the results of SUL administration. Furthermore, SM decreased the levels of IL-6 production and suppressed iNOS and IL-10 mRNA expression in the colon. SM induced significant modulation in gut microbiota by significantly increasing the abundance of Allobaculu. SM also affects the amount of metabolic enzyme classes. In conclusion, we propose that SM may hold promise as a functional food therapeutic approach for the treatment of colitis; however, additional clinical trials are considered necessary to confirm these effects.

Indexed as

Anti-Inflammatory AgentsColitisDextran SulfateGastrointestinal MicrobiomeMorusSynbioticsAnimalsDisease Models, AnimalMaleRatsRats, Sprague-DawleyAnti-Inflammatory AgentsDextran SulfateDextran-sodium-sulfateGut microbiotaInflammatory bowel diseasePro-inflammatory cytokineSynbiotic mulberry

Identifiers

PMID40399636

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.