ArticleNature chemical biology2025
Controlling lipid droplet dynamics via tether condensates.
Article in Nature chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Perilipin-2-Anchored Lipid Droplet-Targeting Phototheranostics.Angewandte Chemie (International ed. in English) · 2026Article
- Lipid droplet dynamics in metabolic regulation.RSC chemical biology · 2026Review
- Recent Advances in Reactive Microdroplets for Clean Water and Energy.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Condensate-mediated intracellular organelle sequestration.Nature reviews. Molecular cell biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid droplets (LDs) are dynamic cellular organelles that regulate lipid metabolism and various cellular processes. Their functionality relies on a dynamic proteome and precise spatiotemporal interactions with other organelles, making LD biology highly complex. Tools that enable the sequestration and release of LDs within their intracellular environment could synchronize their behavior, providing deeper insights into their functions. To address this need, we developed Controlled Trapping of LDs (ControLD), a new method for manipulating LD dynamics. This approach uses engineered condensates to reversibly sequester LDs, temporarily halting their activity. Upon release, the LDs resume their normal functions. ControLD effectively disrupts LD remobilization during metabolic demands and prevents the formation of LD-mitochondria contact sites, which are re-established upon condensate dissociation. ControLD represents a powerful tool for advancing the study of LD biology and opens avenues for investigating and manipulating other cellular organelles.
Indexed as
Identifiers
40399584What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.