Evidence map›Paper›PMID 40399568›Full record

ArticleCalcified tissue international2025

The Association Between Two Different Non-invasive Advanced Glycation End Products and Osteoporosis in the Non-diabetic Population: A Cross-Sectional Study.

Yu-Yi Tian, Lu-Lu Xu, Ya-Qian Fu, Shan Zhou, Chun Yue, Li Hu, Yan-Yi Yang, Yu-Qi Lu, Zhi-Feng Sheng, Li-Hong Liu

Abstract read
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In one paragraph

Article in Calcified tissue international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yu-Yi Tian *Department of Rehabilitation, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Lu-Lu Xu *Health Management Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Ya-Qian FuHealth Management Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Shan ZhouHealth Management Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Chun YueHealth Management Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Li HuHealth Management Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yan-Yi YangHealth Management Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yu-Qi LuXiangya School of Medicine, Central South University, Changsha, Hunan, China.
Zhi-Feng ShengHunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, Health Management Center, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Clinical Medicine Research Center for Intelligent Management of Chronic Disease, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. shengzhifeng@csu.edu.cn.
Li-Hong LiuDepartment of Rehabilitation, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. drliulh@csu.edu.cn.ORCID 0000-0002-2923-3014

Funding

Bethune Charitable Foundation GX2021B04Central South University Educational Reform Research Project 2023jy100Degree& Postgraduate Education Reform Project of Central South University 512190112Hunan Province Basic Education Teaching Reform Research Project Y2024898Hunan Provincial Clinical Medicine Research Center for Intelligent Management of Chronic Disease 2023SK4042Hunan Provincial Health High-level Talents Program, the Fundamental Research Funds for the Central Universities of Central South University 2022ZZTS0947Hunan Provincial Health High-level Talents Program, the Fundamental Research Funds for the Central Universities of Central South University 2023ZZTS0585National Natural Science Foundation of China 81870622National Natural Science Foundation of China 82171581National Undergraduate Innovation and Entrepreneurship Training Program S202410533139Natural Science Foundation of Hunan Province 2022JJ30828Natural Science Foundation of Hunan Province 2023JJ30747Scientific Research Project of Hunan Provincial Health Commission C202303067096
6 · The paper itself

Abstract

Advanced glycation end products (AGEs) are associated with osteoporosis (OP) in the diabetic population. However, their relationship with OP in the non-diabetic population remains unclear. This study aimed to investigate cross-sectional associations of AGEs levels in the skin and lens with OP in the non-diabetic population. A retrospective analysis of clinical data of 652 participants was conducted. Bone mineral density (BMD) was quantified by dual-energy X-ray absorptiometry. Lens and skin AGEs were assessed by lens and skin autofluorescence (LAF and SAF). This study included 652 individuals, 280 males (42.9%) and 372 females (57.1%), with a mean age of (55.5 ± 6.9) years. The population with osteopenia exhibited significantly higher levels of SAF-AGEs than those with normal BMD, while the population with OP had significantly higher levels of both SAF- and LAF-AGEs. After adjusting for age and body mass index, LAF-AGEs were negatively correlated with BMD at the femoral neck and total hip. In contrast, SAF-AGEs were negatively correlated with BMD at the lumbar1-4 spine. Furthermore, multiple linear stepwise regression analysis demonstrated that LAF-AGEs were negatively associated with BMD at both the femoral neck and total hip. However, SAF-AGEs showed no association with BMD at any of the three measured sites. Additionally, after adjusting for other covariates, the logistic regression analysis emphasized that LAF-AGEs were associated with OP in the non-diabetic population, but SAF-AGEs do not. The results revealed a significant correlation between LAF-AGEs and OP in the non-diabetic population and their potential clinical utility warrants further validation. Therefore, we urge for larger longitudinal analyses and experimental research to validate and extend these cross-sectional findings.

Indexed as

Glycation End Products, AdvancedOsteoporosisAbsorptiometry, PhotonAdultAgedBone DensityCross-Sectional StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesSkinGlycation End Products, AdvancedAdvanced glycation end productsBone mineral densityCross-sectional studyOsteopeniaOsteoporosis

Identifiers

PMID40399568

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.