Evidence map›Paper›PMID 40399565›Full record

ArticleMolecular genetics and genomics : MGG2025

The whole genome sequence of Cordyceps cicadae - an edible and potential medicinal fungus.

Yuwei Liu, Xueqian Li, Yiqi Meng, Yifan Wu, Yuting Jin, Xiaotong Ma, Wei Zhou, Yuchong Tan, Fu-Cheng Lin, Hongkai Wang

Abstract read
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In one paragraph

Article in Molecular genetics and genomics : MGG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuwei LiuKey Laboratory of Molecular Biology of Crop Pathogens and Insects of Zhejiang Province, Institute of Biotechnology, Zhejiang University, Hangzhou, China.
Xueqian LiKey Laboratory of Molecular Biology of Crop Pathogens and Insects of Zhejiang Province, Institute of Biotechnology, Zhejiang University, Hangzhou, China.
Yiqi MengKey Laboratory of Molecular Biology of Crop Pathogens and Insects of Zhejiang Province, Institute of Biotechnology, Zhejiang University, Hangzhou, China.
Yifan WuSchool of Medicine, Zhejiang University, Hangzhou, 310058, China.
Yuting JinChengde Medical University, Chengde, Hebei, 067000, The People's Republic of China.
Xiaotong MaDepartment of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Wei ZhouKey Laboratory of Molecular Biology of Crop Pathogens and Insects of Zhejiang Province, Institute of Biotechnology, Zhejiang University, Hangzhou, China.
Yuchong TanState Key Laboratory of Rice Biology, Institute of Biotechnology, Zhejiang University, Hangzhou, 310058, China.
Fu-Cheng LinKey Laboratory of Molecular Biology of Crop Pathogens and Insects of Zhejiang Province, Institute of Biotechnology, Zhejiang University, Hangzhou, China.
Hongkai WangKey Laboratory of Molecular Biology of Crop Pathogens and Insects of Zhejiang Province, Institute of Biotechnology, Zhejiang University, Hangzhou, China. hkwang@zju.edu.cn.ORCID http://orcid.org/0000-0002-6769-9085

Funding

Zhejiang Science and Technology Major Program on Agriculture New Variety Breeding No. 2021C02073-9
6 · The paper itself

Abstract

Cordyceps cicadae is an entomopathogenic fungus from the Cordyceps genus and a well-known edible mushroom with a long history of use in Asia. It contains many bioactive compounds beneficial to human health, giving it broad application prospects in medicine. In this study, we generated the complete genome sequence of C. cicadae strain 2-2 using a combination of Illumina, PacBio, and Hi-C sequencing technologies. This comprehensive genome sequence comprises 9 chromosomes, an N50 contig size of 4,798,690 bp, a GC content ratio of 52.65%, a total size of 34.60 Mb, and 8,019 predicted coding genes. Additionally, we conducted functional annotation of the genome, revealing that 63.2% of the genes were enriched in 50 GO terms and 87.8% in 387 KEGG pathways. We also identified 542 enzyme genes, noting that C. cicadae has a greater number of GHs compared to other fungi in the Cordyceps genus. Notably, NR database analysis revealed that 6,441 genes in C. cicadae are similar to those in Cordyceps fumosorosea, suggesting that C. cicadae may serve as a cost-effective alternative to this expensive traditional medicinal fungus. This study presents the first chromosome-level genome of the Cordyceps genus, providing a comprehensive analysis of the genetic composition and functions of C. cicadae and establishing a foundation for advancing research and development of Cordyceps fungi.

Indexed as

CordycepsGenome, FungalMolecular Sequence AnnotationPhylogenyWhole Genome SequencingCordyceps cicadaeHi-C sequencingWhole genome

Identifiers

PMID40399565

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.