Observational studyScientific reports2025
Clinical and paraclinical features distinguish fatigue from depression-predominant phenotypes in multiple sclerosis.
Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In clinical routine, it might be difficult to distinguish between fatigue and depression in Multiple sclerosis (MS). We investigated in two independent observational cohort studies which clinical and paraclinical features distinguish patients reporting fatigue but no depressive symptoms from those suffering from depressive symptoms but having no relevant fatigue. In Study 1, n = 156 MS patients underwent fatigue, depression, cognitive screening and flow cytometry measurements. In Study 2, n = 54 MS patients performed a comprehensive neuropsychological evaluation. Patients reporting predominantly fatigue symptoms were older, had a lower information processing speed and higher EDSS compared to those scoring high on depression. CD3 + CD4 + T-helper cells count distinguished patients with depressive symptoms from those with neither depression nor fatigue. Study 2 demonstrated similar results. Additionally, progressive MS was associated with fatigue. From the whole neuropsychological test battery only SDMT distinguished fatigue from depressive phenotypes with the latter performing better. In both studies the groups did not differ regarding any other baseline variable including disease activity. Older age, slow information processing, worse physical disability and progressive disease course are distinguishing features of patients reporting more fatigue than depressive symptoms. Higher peripheral inflammatory cell counts seem to characterize depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.