Evidence map›Paper›PMID 40399304›Full record

ReviewCell death discovery2025

Acyl post-translational modification of proteins by metabolites in cancer cells.

Xudong Wang, Yining Guo, Yutian Fu, Chen Zhang, Weiwu Chen, Xinyu Tang, Yanlan Yu, Yicheng Chen, Guoqing Ding, Jie Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xudong WangDepartment of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Yining GuoDepartment of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Yutian FuDepartment of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Chen ZhangDepartment of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Weiwu ChenDepartment of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Xinyu TangDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Yanlan YuDepartment of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. yanlanyu@zju.edu.cn.
Yicheng ChenDepartment of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. chenyicheng@zju.edu.cn.
Guoqing DingDepartment of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 3196014@zju.edu.cn.ORCID http://orcid.org/0000-0003-3156-3618
Jie ZhangDepartment of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 3319019@zju.edu.cn.ORCID http://orcid.org/0000-0002-9957-077X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32000799Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) 2025C02058 to G.D.Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) Y24H160082
6 · The paper itself

Abstract

The relationship between metabolism and cancer is a major focus of current research, with an increasing number of studies highlighting the significant role of various metabolites in tumor cells, such as lactate, acetic acid, lysine, serine, tryptophan, palmitic acid, succinate, etc. These metabolites are involved in numerous biological processes within tumor cells, including transcription, translation, post-translational modification (PTM) of proteins, cell cycle regulation, and metabolism, thereby modulating tumor proliferation, migration, and drug resistance. Metabolite-mediated PTMs of proteins undoubtedly play a vital role in tumor cells, affecting both histones and non-histone proteins, covering modifications such as lactylation, crotonylation, acetylation, palmitoylation, and succinylation. Therefore, this review aims to elaborate on the abnormal levels of some major metabolites, related metabolic pathways, and the latest protein acyl PTMs they mediate in tumor cells, providing new insights for diagnosis and therapy in the field of oncology.

Identifiers

PMID40399304
PMCPMC12095473

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.