Evidence map›Paper›PMID 40399266›Full record

ArticleNature communications2025

Corticothalamic neurons in motor cortex have a permissive role in motor execution.

Lina Marcela Carmona, Anders Nelson, Lin T Tun, An Kim, Rani Shiao, Michael D Kissner, Vilas Menon, Rui M Costa

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lina Marcela CarmonaDepartment of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Anders NelsonCenter for Neural Science, New York University, New York, NY, USA.
Lin T TunDepartment of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
An KimDepartment of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Rani ShiaoLaboratory of Molecular Genetics, The Rockefeller University, New York, NY, USA.
Michael D KissnerColumbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY, USA.
Vilas MenonCenter for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4096-8601
Rui M CostaDepartment of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. rui.costa@alleninstitute.org.ORCID http://orcid.org/0000-0003-0495-8374

Funding

Modeling multi-area dynamics during motor controlU19NS104649 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COSTA, RUI M. · 2017 to 2021
$15.3M
Coordination of Structure and Function in Corticospinal and Corticostriatal PathwaysR00NS118053 · NINDS · NEW YORK UNIVERSITY · PI NELSON, ANDERS · 2023 to 2025
$706k
Dissection of Cell Type Specific Contributions to Motor Learning CircuitsR00NS127857 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Lina Marcela Carmona · 2025 to 2026
$448k
Dissection of Cell Type Specific Contributions to Motor Learning CircuitsK99NS127857 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CARMONA, LINA MARCELA · 2022 to 2023
$272k
Coordination of Structure and Function in Corticospinal and Corticostriatal PathwaysK99NS118053 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NELSON, ANDERS · 2020 to 2021
$251k
A multi-wavelength lighsheet microscope for volumetric imagingS10OD023587 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PETERKA, DARCY S · 2017 to 2017
$236k
NIH HHS S10 OD023587NINDS NIH HHS K99 NS118053NINDS NIH HHS K99 NS127857NINDS NIH HHS R00 NS118053NINDS NIH HHS R00 NS127857NINDS NIH HHS U19 NS104649U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1K99NS127857U.S. Department of Health & Human Services | National Institutes of Health (NIH) 5U19NS104649)
6 · The paper itself

Abstract

The primary motor cortex (M1) is a central hub for motor learning and execution. M1 is composed of heterogeneous cell types with varying relationships to movement. Here, we tagged active neurons at different stages of motor task performance in mice and characterized cell type composition. We identified corticothalamic neurons (M1

Indexed as

Motor CortexNeuronsThalamusAnimalsFemaleForelimbLearningLocomotionMaleMiceMice, Inbred C57BLMovementOptogeneticsPyramidal Tracts

Identifiers

PMID40399266
PMCPMC12095750

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.