Evidence map›Paper›PMID 40399258›Full record

ArticleCell death discovery2025

Gene therapy prevents onset of mitochondrial cardiomyopathy in neonatal mice with Ndufs6 deficiency.

Xiaoxian Zhang, Li Huang, Cheng Li, Jinjuan Yang, Fuyu Duan, Qiang Su, Yuelin Zhang, Meng Kou, Xiaoya Zhou, Liyan Guo and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xiaoxian Zhang *Prenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China.
Li Huang *Prenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China.
Cheng Li *Faculty of Synthetic Biology, Shenzhen University of Advanced Technology; CAS Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Jinjuan YangPrenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China.
Fuyu DuanFaculty of Synthetic Biology, Shenzhen University of Advanced Technology; CAS Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Qiang SuFaculty of Synthetic Biology, Shenzhen University of Advanced Technology; CAS Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Yuelin ZhangDepartment of Emergency Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Meng KouPrenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China.
Xiaoya ZhouPrenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China.
Liyan GuoPrenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China.
Shaoxiang ChenPrenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China.
Yongxia NiuFaculty of Synthetic Biology, Shenzhen University of Advanced Technology; CAS Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Ziyue LiPrenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China.
Sihua OuPrenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China.
Min ZhangFaculty of Synthetic Biology, Shenzhen University of Advanced Technology; CAS Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Kenneth King-Yip ChengDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Jianlong WuDepartment of Pharmacy, Shenzhen Clinical Research Center for Neurological Diseases, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Xiang XuState Key Laboratory of Trauma and Chemical Poisoning, Department of Stem Cell and Regenerative Medicine, Daping Hospital, Army Medical University, Chongqing, China.ORCID http://orcid.org/0000-0002-1026-2210
Qizhou LianPrenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China. qz.lian@siat.ac.cn.ORCID http://orcid.org/0000-0001-8189-7160

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in genes affecting mitochondrial complex I (CI) can lead to mitochondrial cardiomyopathy (MCM) yet no effective treatment. This study sought to determine whether adeno-associated virus 9 (AAV9)-based gene therapy could prevent or rescue Ndufs6 deficiency-induced MCM at different disease stages. Using Ndufs6

Identifiers

PMID40399258
PMCPMC12095822

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.