Evidence map›Paper›PMID 40399089›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Heyde Syndrome Complicated by Alcoholic Liver Cirrhosis in Which Aortic Valve Stenosis Was Diagnosed due to Gastrointestinal Bleeding.

Satomi Hidaka, Masafumi Hashiguchi, Sho Ijuin, Kaori Muromachi, Tsutomu Tamai, Tomoko Kodama, Junichi Nakazawa, Yuichiro Nasu, Takeshi Hori, Hirohito Tsubouchi and 1 more

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Satomi HidakaDepartment of Gastroenterology, Kagoshima City Hospital, Japan.
Masafumi HashiguchiDepartment of Gastroenterology, Kagoshima City Hospital, Japan.
Sho IjuinDepartment of Gastroenterology, Kagoshima City Hospital, Japan.
Kaori MuromachiDepartment of Gastroenterology, Kagoshima City Hospital, Japan.
Tsutomu TamaiDepartment of Gastroenterology, Kagoshima City Hospital, Japan.
Tomoko KodamaDepartment of Gastroenterology, Kagoshima City Hospital, Japan.
Junichi NakazawaDepartment of Gastroenterology, Kagoshima City Hospital, Japan.
Yuichiro NasuDepartment of Gastroenterology, Kagoshima City Hospital, Japan.
Takeshi HoriDepartment of Gastroenterology, Kagoshima City Hospital, Japan.
Hirohito TsubouchiDepartment of Gastroenterology, Kagoshima City Hospital, Japan.
Akio IdoDigestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A man in his 60s with alcoholic cirrhosis experienced repeated gastrointestinal bleeding, and endoscopy revealed angiodysplasia hemorrhaging in the stomach and duodenum. A systolic murmur was heard, and cardiology consultation resulted in the diagnosis of severe aortic stenosis and Heyde syndrome. Gastrointestinal bleeding was resolved after surgical aortic valve replacement. Gastrointestinal bleeding often occurs in patients with cirrhosis and a cardiac examination is recommended if angiodysplasia is observed. This case also suggests that the von Willebrand factor, which is involved in Heyde syndrome, is also closely associated with liver disease.

Indexed as

AngiodysplasiaAortic Valve StenosisGastrointestinal HemorrhageLiver Cirrhosis, AlcoholicHumansMaleMiddle AgedSyndromea disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 13 (ADAMTS13)aortic stenosisHeyde syndromeliver cirrhosisvon Willebrand factor (VWF)

Identifiers

PMID40399089
PMCPMC12740416

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.