Evidence map›Paper›PMID 40399088›Full record

ReviewInternal medicine (Tokyo, Japan)2025

Rheumatoid Meningitis with Generalized Convulsions during Peficitinib Treatment, in Which Anti-cyclic Citrullinated Peptide Antibody in the Cerebrospinal Fluid Was Useful for Making a Diagnosis: A Review of the Literature and Previous Reports.

Shinya Asatani, Noboru Kitamura, Masashi Uchikawa, Kiichi Sugito, Masahiro Nishihara, Yosuke Nagasawa, Hirotame Inomata, Kumiko Akiya, Miho Oshima, Hideki Nakamura

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shinya AsataniDivision of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Japan.
Noboru KitamuraDivision of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Japan.
Masashi UchikawaDivision of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Japan.
Kiichi SugitoDivision of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Japan.
Masahiro NishiharaDivision of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Japan.
Yosuke NagasawaDivision of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Japan.
Hirotame InomataDivision of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Japan.
Kumiko AkiyaDivision of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Japan.
Miho OshimaDivision of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Japan.
Hideki NakamuraDivision of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 80-year-old woman with sudden generalized convulsions was admitted to our hospital. She had a 33-year history of rheumatoid arthritis. Head magnetic resonance imaging (MRI) at the time of admission showed characteristic leptomeningeal findings, and the anti-cyclic citrullinated peptide antibody (ACPA) titer in the cerebrospinal fluid (CSF) was elevated, thus leading to a diagnosis of rheumatoid meningitis (RM). After glucocorticoid treatment, the patient's symptoms promptly improved. RM is often diagnosed using a meningeal biopsy and MRI; however, recent reports have suggested that the CSF ACPA titers (antibody titer index) may also be elevated. In this case, CSF ACPA was useful for making a diagnosis and selecting the optimal treatment modality.

Indexed as

Anti-Citrullinated Protein AntibodiesArthritis, RheumatoidMeningitisSeizuresAged, 80 and overFemaleGlucocorticoidsHumansPeptides, CyclicAnti-Citrullinated Protein Antibodiescyclic citrullinated peptideGlucocorticoidsPeptides, Cyclicantibody indexanti-cyclic citrullinated peptide antibodycerebrospinal fluidgeneralized seizurerheumatoid leptomeningitis

Identifiers

PMID40399088
PMCPMC12740412

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.