Erdheim-Chester Disease Diagnosed by a Pericardial Fluid Cell Block Analysis.

Ikumi Inoue, Yoshio Nakano, Takahiro Hayakawa, Hideki Kosako, Keiya Masuda, Akira Honda, Atsushi Tanaka, Mineo Kurokawa

Abstract readCase Reports

In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ikumi InoueDepartment of Internal Medicine, Kinan Hospital, Japan.

Yoshio NakanoDepartment of Internal Medicine, Naga Hospital, Japan.

Takahiro HayakawaDepartment of Internal Medicine, Kinan Hospital, Japan.

Hideki KosakoHematology/Oncology, Wakayama Medical University, Japan.

Keiya MasudaDepartment of Orthopedic Surgery, Kinan Hospital, Japan.

Akira HondaDepartment of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo, Japan.

Atsushi TanakaCardiovascular Medicine, Wakayama Medical University, Japan.

Mineo KurokawaDepartment of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erdheim-Chester disease (ECD) is a rare histiocytic disorder that poses significant diagnostic challenges owing to its non-specific symptoms. We herein report the case of a 71-year-old woman with exertional dyspnea and bilateral edema who was initially suspected to have heart failure based on cardiomegaly and pericardial effusion. Pericardiocentesis with a cell block analysis revealed histiocytes that were positive for CD68 and negative for CD1a, thus increasing the likelihood of ECD. The bone biopsy results were consistent, thus leading to a diagnosis of ECD. This case highlights the diagnostic utility of a pericardial fluid cell block analysis, which offers a minimally invasive method to identify ECD in patients with significant pericardial effusion.

Indexed as

Erdheim-Chester DiseasePericardial FluidAgedFemaleHumansPericardial EffusionPericardiocentesiscell block analysisErdheim-Chester diseasehistiocytosispericardial effusion

Identifiers

PMID40399087

DOI10.2169/internalmedicine.5424-25

PMCPMC12804443

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.