Evidence map›Paper›PMID 40399085›Full record

ArticleInternal medicine (Tokyo, Japan)2025

A Prompt Diagnosis of Ascites and Dramatic Effect of Alectinib for Advanced Lung Adenocarcinoma Harboring EML4-ALK Fusion.

Takahiro Baba, Hirofumi Inoue, Hiromi Matsuoka, Mio Kyakuno, Yusuke Yoshinaga, Tetsuya Takeguchi, Miho Fujiwara, Kotaro Yamada, Eri Nakamura, Ayako Morita and 12 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Takahiro BabaDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Hirofumi InoueDepartment of Medical Support, Okayama University Hospital, Japan.
Hiromi MatsuokaDepartment of Medical Support, Okayama University Hospital, Japan.
Mio KyakunoDepartment of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Japan.
Yusuke YoshinagaDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Tetsuya TakeguchiDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Miho FujiwaraDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Kotaro YamadaDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Eri NakamuraDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Ayako MoritaDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Naofumi HaraDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Kiichiro NinomiyaCenter for Comprehensive Genomic Medicine, Okayama University Hospital, Japan.
Hisao HigoDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Masanori FujiiDepartment of Geriatric Medicine, Okayama University Hospital, Japan.
Eiki IchiharaCenter for Clinical Oncology, Okayama University Hospital, Japan.
Kammei RaiCenter for Innovative Clinical Medicine, Okayama University Hospital, Japan.
Kadoaki OhashiDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Katsuyuki HottaCenter for Innovative Clinical Medicine, Okayama University Hospital, Japan.
Masahiro TabataCenter for Clinical Oncology, Okayama University Hospital, Japan.
Yoshinobu MaedaDepartment of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan.
Yosuke TogashiDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Go MakimotoDepartment of Respiratory Medicine, Okayama University Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 75-year-old never-smoker woman presented with dyspnea and loss of appetite. A mass was identified in the left upper lobe of the lung, and the patient was referred to our hospital. Despite the diagnosis of lung adenocarcinoma via bronchoscopy, anaplastic lymphoma kinase (ALK) immunostaining was negative. Rapid weight gain and abdominal distension caused by ascites prompted fluid testing using the AmoyDx

Indexed as

AdenocarcinomaAscitesCarbazolesLung NeoplasmsOncogene Proteins, FusionPiperidinesAdenocarcinoma of LungAgedFemaleHumansProtein Kinase InhibitorsTreatment OutcomealectinibCarbazolesEML4-ALK fusion protein, humanOncogene Proteins, FusionPiperidinesProtein Kinase InhibitorsalectinibAmoyDx® Pan Lung Cancer PCR PanelEML4-ALKlung adenocarcinoma

Identifiers

PMID40399085
PMCPMC12740353

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.