Blue Toe Syndrome Responding to Direct Hemoadsorption Therapy with the Rheocarna

Junichiro Nishiyama, Keiichi Aoyagi, Kazuyoshi Tsuru, Sayaka Tsubaki, Sae Imamura, Yuma Nagahama

Abstract readCase Reports

In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junichiro NishiyamaSeisyukai Clinic, Japan.

Keiichi AoyagiRenal Center, Seisyukai Clinic, Japan.

Kazuyoshi TsuruRenal Center, Seisyukai Clinic, Japan.

Sayaka TsubakiRenal Center, Seisyukai Clinic, Japan.

Sae ImamuraRenal Center, Seisyukai Clinic, Japan.

Yuma NagahamaRenal Center, Seisyukai Clinic, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A man in his 80s who was on maintenance dialysis and warfarin therapy for atrial fibrillation developed sudden mottled cyanosis and multiple ulcers on his toes, without any apparent trigger. Despite no significant stenosis in the lower extremity arteries, he had a shaggy mural thrombus in the abdominal aorta, leading to a diagnosis of blue toe syndrome. Conservative treatment was ineffective, prompting the use of a novel apheresis device (Rheocarna

Indexed as

Blood Component RemovalBlue Toe SyndromeAged, 80 and overHumansMaleTreatment Outcomeblue toe syndromecholesterol crystal embolismlow-density lipoprotein apheresisRheocarna®toe ulcer

Identifiers

PMID40399083

DOI10.2169/internalmedicine.5327-25

PMCPMC12740409

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.