Evidence map›Paper›PMID 40399081›Full record

ReviewInternal medicine (Tokyo, Japan)2026

Gut Microbiota and Interorgan Communication Among the Gut, Brain, and Beyond.

Arina Shigehara, Hiroki Kiyohara, Toshiaki Teratani, Nobuhiro Nakamoto, Yohei Mikami, Takanori Kanai

Abstract readReview
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arina ShigeharaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan.
Hiroki KiyoharaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan.
Toshiaki TerataniDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan.
Nobuhiro NakamotoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan.
Yohei MikamiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan.
Takanori KanaiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestinal tract contains the largest reservoir of lymphoid tissue in the body and it communicates with other organs through metabolites, cytokine activation, and the migration of gut immune cells. In particular, the liver interacts with the gut through the portal vein and bile ducts. Furthermore, the frequent abdominal symptoms reported by patients with neuropsychiatric disorders underscore a strong gut-brain connection. Gut-liver and gut-brain interactions have received increasing attention in recent years, and numerous studies have been performed in the last decade. Research is now being actively conducted to determine the specific bacteria associated with the development and progression of various diseases. This review summarizes recent findings, with a focus on the links between gut immunity and other organs.

Indexed as

BrainBrain-Gut AxisGastrointestinal MicrobiomeGastrointestinal TractAnimalsHumansLiverbiologicsgut brain axisinflammatory bowel diseaseinterorgan communicationmetabolic dysfunction-associated liver diseasemicrobiota

Identifiers

PMID40399081
PMCPMC12900593

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.