Evidence map›Paper›PMID 40398972›Full record

ArticleJournal of the American College of Cardiology2025

Serum Transthyretin as a Biomarker of Treatment Response in ATTR Cardiomyopathy.

Jessica A Regan, Michelle M Kittleson, Michel G Khouri, Frederick L Ruberg, Senthil Selvaraj

Abstract readEditorial
In one paragraph

Article in Journal of the American College of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jessica A ReganDivision of Cardiology, Duke University School of Medicine, Durham, North Carolina, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.
Michelle M KittlesonDepartment of Cardiology, Smidt Heart Institute, Los Angeles, California, USA.
Michel G KhouriDivision of Cardiology, Duke University School of Medicine, Durham, North Carolina, USA.
Frederick L RubergSection of Cardiovascular Medicine and Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, Massachusetts, USA.
Senthil SelvarajDivision of Cardiology, Duke University School of Medicine, Durham, North Carolina, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA. Electronic address: senthil.selvaraj@duke.edu.

Funding

SCAN-MP (Screening for Cardiac Amyloidosis with Nuclear imaging in Minority Populations) COVID-19 SuppplementR01HL139671 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAURER, MATHEW S, RUBERG, FREDERICK LIEF · 2019 to 2023
$7.4M
Dissecting the Ketone Metabolic Axis in Heart Failure with Reduced Ejection FractionK23HL161348 · NHLBI · DUKE UNIVERSITY · PI Senthil Selvaraj · 2022 to 2026
$1.0M
Age-Related Clonal Hematopoiesis of Indeterminate Potential (CHIP) in Exercise ResponsivenessK38HL175026 · NHLBI · DUKE UNIVERSITY · PI REGAN, JESSICA ANN · 2024 to 2025
$210k
NHLBI NIH HHS K23 HL161348NHLBI NIH HHS K38 HL175026NHLBI NIH HHS R01 HL139671
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acoramidisall-cause mortalityATTR-CMserum TTRtransthyretinTTR stabilization

Identifiers

PMID40398972
PMCPMC12163915

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.