Evidence map›Paper›PMID 40398932›Full record

ArticleBMJ open2025

The effect of topical TRanexamic Acid versus placebo on acute postoperative pain following Distal Radius fracture fixation: protocol for a randomised controlled trial at a quaternary care hand surgery centre - The TRADR study.

Darius Luke Lameire, Atefeh Noori, Aazad Abbas, Jonathan Persitz, Heather Baltzer, Emily Collett, Christian Veillette, Andrea Chan, Ryan Paul

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06384456 (The Effect of Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following Distal Radius Fracture Fixation), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06384456 phase4recruitingnot on this map

The Effect of Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following Distal Radius Fracture Fixation: a Randomized Controlled Trial - The TRADR Study

TypeinterventionalSponsorUniversity Health Network, TorontoRan2025 to 2027Enrolled90ConditionsDistal Radius FracturesArmsTopical TRanexamic Acid, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Darius Luke LameireDivision of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-1051-3144
Atefeh NooriDivision of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, University Health Network; Toronto Western Hand Program, University of Toronto, Toronto, Ontario, Canada.
Aazad AbbasDivision of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Jonathan PersitzDivision of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, University Health Network; Toronto Western Hand Program, University of Toronto, Toronto, Ontario, Canada.
Heather BaltzerDivision of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, University Health Network; Toronto Western Hand Program, University of Toronto, Toronto, Ontario, Canada.
Emily CollettSchroeder Arthritis Institute & Krembil Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Christian VeilletteDivision of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Andrea ChanDivision of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Ryan PaulDivision of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada ryan.paul2@uhn.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPostoperative pain management is a major concern for patients undergoing distal radius open reduction internal fixation (ORIF). Inadequate pain control negatively impacts patient's satisfaction and may increase opioid use. Topical tranexamic acid (TXA) has been demonstrated as an effective intervention that reduced acute postoperative pain in total knee arthroplasty. There is no study evaluating the effects of TXA on acute postoperative pain for distal radius ORIF. This study aims to evaluate the effect of topical TXA administration during isolated distal radius ORIF on early postoperative pain. METHODS AND ANALYSIS: The effect of topical TRanexamic Acid versus placebo on acute postoperative pain following Distal Radius fracture fixation (TRADR) study is a randomised controlled double-blinded trial that will enrol 90 patients, 18 years of age or older, undergoing volar open reduction internal fixation. Patients will be randomly assigned to topical TXA versus topical saline (placebo) in a 1:1 ratio. The surgeon at the time of surgical closure after standard distal radius fixation will apply either 1 g of topical TXA (100 mg/mL; treatment group) or 10 mL of saline (control group) to the wound and let it sit for 5 min. Surgeons, patients, and outcome assessors will be blinded to the treatment group. The primary outcome is acute postsurgical pain as measured by the visual analogue scale (VAS). Pain outcomes will be between postoperative days 0 to 7, and at 2 and 6 weeks postsurgery. The secondary outcomes include opioid usage, unscheduled emergency visits, wrist swelling and adverse events. ETHICS AND DISSEMINATION: This study was approved by the University Health Network Research Ethics Board (REB 23-5708). The results of this trial will be disseminated through peer-reviewed journals and presented at related conferences. The principal investigator will communicate the results with patients who have indicated an interest in knowing the results. TRIAL REGISTRATION NUMBER: Clinicaltrials.gov NCT06384456, April 26, 2024; Pre-enrolment. PROTOCOL VERSION: Version 2.0: August 26, 2024.

Indexed as

Acute PainAntifibrinolytic AgentsFracture Fixation, InternalPostoperative PainRadius FracturesTranexamic AcidAdministration, TopicalAdultDouble-Blind MethodFemaleHumansMaleMiddle AgedOpen Fracture ReductionPain MeasurementRandomized Controlled Trials as TopicAntifibrinolytic AgentsTranexamic AcidHand & wristORTHOPAEDIC & TRAUMA SURGERYPAIN MANAGEMENT

Identifiers

PMID40398932
PMCPMC12097037

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.