ArticleSleep2025
One size fits null: attentional brain responses differ depending on insomnia subtype.
Article in Sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The efficacy and safety of trazodone for sleep problems in depressive patients: a GRADE-assessed systematic review and meta-analysis of clinical trials.Psychopharmacology · 2026Pooled it
- Hyperarousal transdiagnostically dissected: different dimensions characterize mood, anxiety, insomnia, posttraumatic stress and attention deficit hyperactivity disorders.EClinicalMedicine · 2026Article
- Subtyping insomnia disorder with a population graph attention autoencoder: revealing two distinct biotypes.Frontiers in neuroscience · 2026Article
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8 authors.
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Abstract
STUDY
objectivesEvent-related potential (ERP) studies on attentional brain processes in insomnia disorder (ID) have yielded inconsistent findings. Such inconsistencies may relate to small sample sizes, limited corrections for multiple comparisons, and the possibility of heterogeneity within the clinical population. We aimed to overcome these limitations by studying ERP responses both across and within subtypes in a larger sample of ID.
methodsERPs were recorded in 201 participants with ID and 70 normal sleeper controls (NS) with an auditory oddball task. Participants with ID were subtyped using a validated multivariate trait profile. Analyses evaluated subtype-specific and nonspecific deviations using both conventional ERP components as well as cluster-based permutation tests.
resultsAll five subtypes were well-represented in the ID sample (subtypes 1-5 respectively N = 31, 83, 28, 29 and 19). ERP component analyses with false discovery rate corrections revealed no evidence for differences between the heterogeneous ID group and NS. However, subtype-specific analyses revealed that ERPs were significantly altered, but in different ways for different subtypes. Specifically, ERP component analyses revealed stronger N100 amplitudes for standards and deviants both in subtypes 2 and 3, and a lower P300 amplitude and longer P300 latency for deviants in subtype 3. Cluster-based permutation tests on ERPs corroborated the P300 amplitude effect for deviants in subtype 3, with subtype 3 and 4 additionally showing a smaller difference between deviant and standard P300 amplitudes.
conclusionOur findings indicate that ID is a heterogeneous disorder. Ignoring subtype identity dilutes ERP alterations occurring only in specific insomnia subtypes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.