ArticleOrganic letters2025
Generation and Use of Cyclopropenyllithium under Continuous Flow Conditions.
Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Single-carbon insertion enables conversion of cyclopropenes into cyclobutenes: access to oxaspiro[2.3]hexenes.Chemical science · 2026Article
- Advances in Flow Chemistry for Organolithium-Based Synthesis: A Process Perspective.Molecules (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cyclopropene scaffold has emerged as a valuable platform in modern synthesis. Here, we present a streamlined flow-based approach for the generation of cyclopropenyllithium and its functionalization with various electrophiles in a single, continuous flow process. This method eliminates the need for laborious temperature changes and cryogenic conditions, and significantly reduces the process time from starting material to products. Compared to traditional batch processes, our flow approach enables the use of a single organolithium reagent and operates efficiently at 0 °C, avoiding the cool-warm-cool temperature cycles typical of batch methods. This not only simplifies the workflow but also enhances practicality, scalability, and extends the accessible chemical space.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.