ReviewFertility and sterility2025
Male fertility restoration with stem cell-based therapies: from testicular stem cells to pluripotent stem cell-based in vitro gametogenesis.
Review in Fertility and sterility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Epidemiology, Etiopathogenesis, Diagnosis, and Treatment of Male Infertility-Current Trends and Future Directions: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- The Use of Stem Cells in Assisted Reproduction.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Male factor infertility poses a substantial clinical challenge, affecting 8%-12% of couples worldwide. The underlying causes of this condition range from cancer treatments to congenital disorders. The present approach to fertility preservation entails the cryopreservation of sperm for postpubertal males. However, this method offers limited options for prepubertal patients and those with nonobstructive azoospermia. This review examines emerging stem cell-based therapies, including testicular tissue grafting, organ culture, cell reconstitution, spermatogonial stem cell transplantation, and pluripotent stem cell-derived in vitro gametogenesis. Although these approaches have demonstrated notable efficacy in animal models, particularly in mice, translating these technologies into clinical applications is confronted by significant scientific, ethical, and regulatory challenges. These innovative stem cell strategies offer promising pathways to restore fertility potential and provide hope for patients currently without reproductive options.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.