Evidence map›Paper›PMID 40398584›Full record

ArticleMagnetic resonance imaging2025

Harmonized connectome resampling for variance in voxel sizes.

Elyssa M McMaster, Nancy R Newlin, Gaurav Rudravaram, Adam M Saunders, Aravind R Krishnan, Lucas W Remedios, Michael E Kim, Hanliang Xu, Jongyeon Yoon, Derek B Archer and 4 more

Abstract read
In one paragraph

Article in Magnetic resonance imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Personalized White Matter Bundle Segmentation for Early Childhood.Proceedings of SPIE--the International Society for Optical Engineering · 2026
    Article
  6. Article
  7. Modeling a Shared Reality of Tractography through Varied Structural Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2026
    Article
  8. Article
  9. Tractography enhancement in clinically-feasible diffusion MRI using T1-weighted MRI and anatomical context.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Elyssa M McMasterDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA. Electronic address: elyssa.m.mcmaster@vanderbilt.edu.
Nancy R NewlinDepartment of Computer Science, Vanderbilt University, Nashville, TN, USA.
Gaurav RudravaramDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.
Adam M SaundersDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.
Aravind R KrishnanDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.
Lucas W RemediosDepartment of Computer Science, Vanderbilt University, Nashville, TN, USA.
Michael E KimDepartment of Computer Science, Vanderbilt University, Nashville, TN, USA.
Hanliang XuDepartment of Computer Science, Vanderbilt University, Nashville, TN, USA.
Jongyeon YoonDepartment of Computer Science, Vanderbilt University, Nashville, TN, USA.
Derek B ArcherVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Kurt G SchillingVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
François RheaultDepartment of Computer Science, Université de Sherbrooke, Sherbrooke, QC, Canada.
Laurie E CuttingDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Kennedy Center, Vanderbilt University, Nashville, TN, USA; Peabody College of Education, Vanderbilt University, Nashville, TN, USA.
Bennett A LandmanDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA; Department of Computer Science, Vanderbilt University, Nashville, TN, USA; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
MVP Data Integration into the ADSP Phenotype Harmonization ConsortiumU24AG074855 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUCCARO, MICHAEL L, HOHMAN, TIMOTHY J · 2021 to 2025
$37.5M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Controlling Quality and Capturing Uncertainty in Advanced Diffusion Weighted MRIR01EB017230 · NIBIB · VANDERBILT UNIVERSITY · PI LANDMAN, BENNETT A. · 2015 to 2024
$5.1M
Integrated Training in Engineering and DiabetesT32DK101003 · NIDDK · VANDERBILT UNIVERSITY · PI Jamey D. Young · 2014 to 2026
$3.9M
Novel Integrative Approach for the Early Detection of Lung Cancer using Repeated MeasuresR01CA253923 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LANDMAN, BENNETT A., MALDONADO, FABIEN · 2021 to 2025
$3.4M
NCATS NIH HHS UL1 TR002243NCI NIH HHS R01 CA253923NIA NIH HHS U24 AG074855NIBIB NIH HHS R01 EB017230NICHD NIH HHS P50 HD103537NIDDK NIH HHS T32 DK101003
6 · The paper itself

Abstract

Diffusion MRI (dMRI) fiber tractography presents exciting opportunities to deepen our knowledge of human brain connectivity and discover novel alterations in white matter. To date, there has been no comprehensive study characterizing the effect of dMRI voxel resolution on the resulting connectome for subject data. We assessed the statistical significance of graph measures derived from dMRI data by comparing connectomes from the same scans across different resolutions with 44 subjects (32 female) from the Human Connectome Project - Young Adult dataset (HCP-YA) with scan/rescan data (88 scans). We explored 15 isotropic and anisotropic resolutions, generated tractography and connectomes, and compared graph measures between each resolution and its nearest larger and smaller resolutions. Nearly all pairwise comparisons yielded statistically significant differences in graph measures (p ≤ 0.05, Wilcoxon Sign-Rank Test). Upon up sampling the 14 down sampled resolutions in 0.5 mm increments, we observed mitigation of the spatial sampling effect on both the tractography and the connectome's complex graph measures. To investigate translational impact, we resampled 22 subjects from HCP-YA to the resolutions of two major national studies and up-sampled this data back to 1 mm isotropic with different interpolation methods. Similarity in results improved with higher resolution, even after initial down-sampling. To ensure robust tractography and connectomes, resample data to 1 mm isotropic resolution.

Indexed as

BrainConnectomeDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingWhite MatterAdultAnisotropyFemaleHumansImage Processing, Computer-AssistedMaleReproducibility of ResultsYoung AdultConnectomicsDiffusion MRIHarmonizationSpatial samplingTractography

Identifiers

PMID40398584
PMCPMC13249084

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.