ArticleThe Journal of arthroplasty2025
Long-Term Risk of Heart Failure in Total Joint Arthroplasty: A Population-Based Cohort Study.
Article in The Journal of arthroplasty, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundPrevious case reports raised concerns about the cardiovascular effects of metal particles and ions produced by mechanical wear and corrosion of total joint arthroplasty (TJA) implants. We compared the long-term risk of heart failure in a cohort of individuals who had TJA and in a general population comparison cohort.
methodsThis was a population-based, retrospective cohort study of 7,182 TJA subjects who first had total hip arthroplasty (THA) or total knee arthroplasty surgeries between 1990 and 2020 and 7,407 age-, sex-, and calendar year-matched non-TJA subjects. All subjects were followed up until death, incident heart failure, migration, or 2020. The medical records were reviewed to collect data on surgical history, cardiovascular risk factors, and heart failure outcomes. Poisson regression models were used to estimate the risk of heart failure in TJA subjects, accounting for the competing risk of death and adjusting for cardiovascular risk factors.
resultsAt baseline, TJA subjects had a higher prevalence of several cardiovascular risk factors than the non-TJA subjects. The risk of heart failure in TJA subjects was similar to the general population during the first decade after surgery. However, the risk increased over time, and by the second decade after surgery, the risk of heart failure in both the THA (hazard ratio 1.34, 95% confidence interval [CI]: 1.13 to 1.58) and total knee arthroplasty (hazard ratio 1.33, 95% confidence interval: 1.16 to 1.53) subjects was higher than the non-TJA subjects. The long-term risk of heart failure was higher among THA subjects with cobalt-chromium-containing implants and those who underwent surgery for fractures and inflammatory arthritis.
conclusionsWe observed a higher risk of heart failure beyond the first decade after TJA surgery. However, the magnitude of the risk is small and should be interpreted with caution due to the possibility of informative presence and confounding bias.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.