Evidence map›Paper›PMID 40398512›Full record

ReviewAsia-Pacific journal of ophthalmology (Philadelphia, Pa.)

Geographic atrophy: Understanding the relationship between structure and function.

Antoine Huang, Zhichao Wu, Georg Ansari, Leon Von Der Emde, Maximilian Pfau, Steffen Schmitz-Valckenberg, Monika Fleckenstein, Tiarnán D L Keenan, Srinivas R Sadda, Robyn H Guymer and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Asia-Pacific journal of ophthalmology (Philadelphia, Pa.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Antoine HuangSingapore National Eye Centre, Singapore; Sorbonne Université, Paris, France.
Zhichao WuCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Australia.
Georg AnsariDepartment of Ophthalmology, University of Basel, Basel, Switzerland.
Leon Von Der EmdeDepartment of Ophthalmology, University of Bonn, Bonn, Germany; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Maximilian PfauDepartment of Ophthalmology, University of Basel, Basel, Switzerland; Department of Ophthalmology, University of Bonn, Bonn, Germany; Roche Pharmaceutical Research and Early Development, Translational Medicine Ophthalmology, Roche Innovation Center Basel, Basel, Switzerland.
Steffen Schmitz-ValckenbergDepartment of Ophthalmology, University of Bonn, Bonn, Germany; John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
Monika FleckensteinJohn A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
Tiarnán D L KeenanDivision of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Srinivas R SaddaDoheny Eye Institute, Pasadena, CA, USA; Department of Ophthalmology, University of California - Los Angeles, Los Angeles, CA, USA.
Robyn H GuymerCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Australia.
Chui Ming Gemmy CheungSingapore National Eye Centre, Singapore; Singapore Eye Research Institute, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore.
Usha ChakravarthyCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom. Electronic address: u.chakravarthy@qub.ac.uk.

Funding

University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jun Yang · 2005 to 2026
$14.6M
NEI Intramural Biorepository for Retinal Diseases (12-EI-0042)ZIAEY000514 · NEI · NATIONAL EYE INSTITUTE · PI KEENAN, TIARNAN · 2012 to 2025
$2.0M
Intramural NIH HHS ZIA EY000514NEI NIH HHS P30 EY014800
6 · The paper itself

Abstract

purposeThis review explores the complex relationship between anatomical alterations and functional consequences in geographic atrophy (GA), the advanced non-neovascular form of age-related macular degeneration. We examine the natural history, progression patterns, structural biomarkers, functional assessments, and structure-function correlations in GA.

methodsExperts contributed specialized knowledge on GA pathophysiology, imaging biomarkers, and functional assessment methods. We synthesized an understanding of the relationship between structural changes (including fundus autofluorescence patterns, optical coherence tomography markers, and novel biomarkers) and functional outcomes (visual acuity, microperimetry, reading performance, and patient-reported outcomes), drawing from authors' research expertise and relevant literature.

resultsWhile GA is defined by visible areas of outer retinal atrophy, the structure-function relationship is complex and often discordant. Visual acuity incompletely reflects the functional impact of GA, as it may remain preserved until foveal involvement occurs. Microperimetric assessments reveal functional deficits extending beyond visible atrophic borders, with varying degrees of correlation between structural and functional metrics. Different fundus autofluorescence patterns demonstrate distinct functional implications and progression rates. Recent innovations in imaging and visual function testing offer enhanced characterization of disease progression.

conclusionsThe complex relationship between structural and functional measures in GA reflects underlying pathophysiological mechanisms and has important implications for clinical trial endpoints and patient management. Multimodal assessment incorporating both structural and functional parameters is essential for the comprehensive evaluation and management of GA, particularly as novel therapeutic approaches emerge.

Indexed as

Geographic AtrophyTomography, Optical CoherenceVisual AcuityVisual FieldsDisease ProgressionFluorescein AngiographyHumansVisual Field TestsAge-related macular degenerationFundus autofluorescenceGeographic atrophyMicroperimetryStructure-function correlation

Identifiers

PMID40398512
PMCPMC12235197

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.