Evidence map›Paper›PMID 40398404›Full record

ArticleNeuroendocrinology2025

Sensorimotor Development in Rat Neonates Exposed to 17-α-Hydroxyprogesterone Caproate: A Progestin Used in Obstetrics.

Paige L Graney, Evelyn L Sarno, Jessie E Miller, Christine K Wagner

Abstract read
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In one paragraph

Article in Neuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paige L GraneyDepartment of Psychology and Center for Neuroscience Research, University at Albany, Albany, New York, USA.
Evelyn L SarnoDepartment of Psychology and Center for Neuroscience Research, University at Albany, Albany, New York, USA.
Jessie E MillerDepartment of Psychology and Center for Neuroscience Research, University at Albany, Albany, New York, USA.
Christine K WagnerDepartment of Psychology and Center for Neuroscience Research, University at Albany, Albany, New York, USA.

Funding

Cortical and Cognitive Development Following Synthetic Progestin ExposureR01HD093907 · NICHD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI WAGNER, CHRISTINE K · 2018 to 2023
$1.6M
NICHD NIH HHS R01 HD093907
6 · The paper itself

Abstract

introduction17-α-hydroxyprogesterone caproate (17-OHPC) is prescribed to pregnant individuals at risk for preterm birth during critical periods of fetal cortical maturation. Yet the potential long-term effects of 17-OHPC on neural and behavioral development in children are unknown. Nuclear progesterone receptor (PR) is expressed in all functional regions of rat cortex during development. The hypothesis that developmental exposure to 17-OHPC alters sensorimotor development was tested.

methodsSensorimotor behaviors were observed in neonates administered 17-OHPC from the day of birth through postnatal day 11, and PR was quantified in cortex at P11.

results17-OHPC administration resulted in a disruption in sensorimotor indicators of typical brain development, without affecting gross motor function. 17-OHPC-exposed rats had significantly fewer PR-immunoreactive nuclei in somatosensory cortex.

conclusionsThese findings demonstrate that 17-OHPC exposure during critical periods of cortical development may impact sensorimotor development and cortical sensitivity to progestins, highlighting the need for further investigation on the clinical implications of this progestin.

Indexed as

Prenatal Exposure Delayed EffectsProgestinsSensorimotor CortexSomatosensory Cortex17 alpha-Hydroxyprogesterone CaproateAnimalsAnimals, NewbornFemaleMalePregnancyRatsRats, Sprague-DawleyReceptors, Progesterone17 alpha-Hydroxyprogesterone CaproateProgestinsReceptors, Progesterone17-OHPCCortical developmentProgesterone receptorSensorimotor behaviorsSomatosensory cortex

Identifiers

PMID40398404
PMCPMC12343196

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.