Evidence map›Paper›PMID 40397927›Full record

ArticleJMIR mental health2025

A Comparison of Responses from Human Therapists and Large Language Model-Based Chatbots to Assess Therapeutic Communication: Mixed Methods Study.

Till Scholich, Maya Barr, Shannon Wiltsey Stirman, Shriti Raj

Abstract readComparative Study
In one paragraph

Article in JMIR mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Till ScholichInstitute for Human-Centered AI, Stanford University, Stanford, CA, United States.ORCID 0009-0002-4307-8724
Maya BarrPGSP-Stanford PsyD Consortium, Palo Alto University, Palo Alto, CA, United States.ORCID 0000-0002-5040-6581
Shannon Wiltsey StirmanDissemination and Training Division, National Center for PTSD, Menlo Park, CA, United States.ORCID 0000-0001-9917-5078
Shriti RajInstitute for Human-Centered AI, Stanford University, Stanford, CA, United States.ORCID 0000-0001-5484-9980

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConsumers are increasingly using large language model-based chatbots to seek mental health advice or intervention due to ease of access and limited availability of mental health professionals. However, their suitability and safety for mental health applications remain underexplored, particularly in comparison to professional therapeutic practices.

objectiveThis study aimed to evaluate how general-purpose chatbots respond to mental health scenarios and compare their responses to those provided by licensed therapists. Specifically, we sought to identify chatbots' strengths and limitations, as well as the ethical and practical considerations necessary for their use in mental health care.

methodsWe conducted a mixed methods study to compare responses from chatbots and licensed therapists to scripted mental health scenarios. We created 2 fictional scenarios and prompted 3 chatbots to create 6 interaction logs. We recruited 17 therapists and conducted study sessions that consisted of 3 activities. First, therapists responded to the 2 scenarios using a Qualtrics form. Second, therapists went through the 6 interaction logs using a think-aloud procedure to highlight their thoughts about the chatbots' responses. Finally, we conducted a semistructured interview to explore subjective opinions on the use of chatbots for supporting mental health. The study sessions were analyzed using thematic analysis. The interaction logs from chatbot and therapist responses were coded using the Multitheoretical List of Therapeutic Interventions codes and then compared to each other.

resultsWe identified 7 themes describing the strengths and limitations of the chatbots as compared to therapists. These include elements of good therapy in chatbot responses, conversational style of chatbots, insufficient inquiry and feedback seeking by chatbots, chatbot interventions, client engagement, chatbots' responses to crisis situations, and considerations for chatbot-based therapy. In the use of Multitheoretical List of Therapeutic Interventions codes, we found that therapists evoked more elaboration (Mann-Whitney U=9; P=.001) and used more self-disclosure (U=45.5; P=.37) as compared to the chatbots. The chatbots used affirming (U=28; P=.045) and reassuring (U=23; P=.02) language more often than the therapists. The chatbots also used psychoeducation (U=22.5; P=.02) and suggestions (U=12.5; P=.003) more often than the therapists.

conclusionsOur study demonstrates the unsuitability of general-purpose chatbots to safely engage in mental health conversations, particularly in crisis situations. While chatbots display elements of good therapy, such as validation and reassurance, overuse of directive advice without sufficient inquiry and use of generic interventions make them unsuitable as therapeutic agents. Careful research and evaluation will be necessary to determine the impact of chatbot interactions and to identify the most appropriate use cases related to mental health.

Indexed as

Attitude of Health PersonnelCommunicationHealth PersonnelMental DisordersProfessional-Patient RelationsPsychotherapyAdultFemaleGenerative Artificial IntelligenceHumansLarge Language ModelsMaleMiddle AgedAIAI therapyartificial intelligenceartificial intelligence therapylarge language modellarge language modelsLLMmental healththerapists

Identifiers

PMID40397927
PMCPMC12138294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.