ArticleJMIR mental health2025
A Comparison of Responses from Human Therapists and Large Language Model-Based Chatbots to Assess Therapeutic Communication: Mixed Methods Study.
Article in JMIR mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Efficacy of Rule-Based Versus Large Language Model-Based Chatbots in Alleviating Symptoms of Depression and Anxiety: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- A cognitive layer architecture to support large-language model performance in psychotherapy interactions.Nature medicine · 2026Trial
- Are You Qualified, ChatGPT? Examining Clinical Skills and Competencies of ChatGPT in Delivering Systemic Interventions.Journal of marital and family therapy · 2026Article
- Exploring Real-World Use of AI Chatbots for Mental Health Support: Cross-Sectional Survey Study.JMIR mental health · 2026Article
- Generative Large Language Models in Mental Health Care Settings: Systematic Review and Meta-Analysis.JMIR AI · 2026Review
- Artificial Intelligence Applications in Mental Health: A Systematic Review of Clinical Practice, Educational Transformation, and Ethical Governance.Healthcare (Basel, Switzerland) · 2026Review
- A scoping review on the mental health harms of LLM-based chatbots.NPJ digital medicine · 2026Article
- Multiagent Large Language Model Framework for Psychotherapy Fidelity Assessment in Motivational Interviewing and Cognitive Behavioral Therapy Training: Cross-Sectional, Simulation-Based Evaluation Study.JMIR medical education · 2026Article
- Health Care Professionals' Perspectives on Conversational Mental Health Chatbots: Protocol for a Systematic Review.JMIR research protocols · 2026Article
- Real-world use of large language models for mental health in 2024.NPJ digital medicine · 2026Article
- Applications, Challenges, and Future Directions of Large Language Models in Health Care Communication: Scoping Review.Journal of medical Internet research · 2026Article
- Pilot of a blended learning model on medical students' communication skills in the context of digital innovations.BMC medical education · 2026Article
- Automated Safety Testing and Reporting Application for Conversational Safety Monitoring of Generative AI Tools for Mental Health: Development and Validation Study.JMIR mental health · 2026Article
- Barriers and Facilitators to the Use of Large Language Model-Based Conversational Agents in Mental Healthcare: A Systematic Review.Healthcare (Basel, Switzerland) · 2026Review
- Generative Artificial Intelligence as a Psychological Intervention: Between Illusion and Risk.Journal of medical systems · 2026Article
- Bridging Science and Subjectivity: Evolving Evidence, Emerging Technologies and the Call for Personalised Psychotherapy: Créer une passerelle entre la science et la subjectivité : Évolution des données probantes, arrivée de nouvelles technologies et appel à une psychothérapie personnalisée.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2026Article
- Evaluating the Efficacy of AI-Based Interactive Assessments Using Large Language Models for Depression Screening: Development and Usability Study.JMIR formative research · 2026Article
- Cybersecurity and Privacy Risks of Generative AI Mental-Health Chatbots: A Systematic Review and Regulatory Framework.Journal of multidisciplinary healthcare · 2026Review
- Trauma-informed conversational agents for mental health: understanding user perspectives and experiences.Frontiers in digital health · 2026Article
- Generative AI as a de facto mental health provider: a policy brief and urgent call for regulation.Frontiers in digital health · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConsumers are increasingly using large language model-based chatbots to seek mental health advice or intervention due to ease of access and limited availability of mental health professionals. However, their suitability and safety for mental health applications remain underexplored, particularly in comparison to professional therapeutic practices.
objectiveThis study aimed to evaluate how general-purpose chatbots respond to mental health scenarios and compare their responses to those provided by licensed therapists. Specifically, we sought to identify chatbots' strengths and limitations, as well as the ethical and practical considerations necessary for their use in mental health care.
methodsWe conducted a mixed methods study to compare responses from chatbots and licensed therapists to scripted mental health scenarios. We created 2 fictional scenarios and prompted 3 chatbots to create 6 interaction logs. We recruited 17 therapists and conducted study sessions that consisted of 3 activities. First, therapists responded to the 2 scenarios using a Qualtrics form. Second, therapists went through the 6 interaction logs using a think-aloud procedure to highlight their thoughts about the chatbots' responses. Finally, we conducted a semistructured interview to explore subjective opinions on the use of chatbots for supporting mental health. The study sessions were analyzed using thematic analysis. The interaction logs from chatbot and therapist responses were coded using the Multitheoretical List of Therapeutic Interventions codes and then compared to each other.
resultsWe identified 7 themes describing the strengths and limitations of the chatbots as compared to therapists. These include elements of good therapy in chatbot responses, conversational style of chatbots, insufficient inquiry and feedback seeking by chatbots, chatbot interventions, client engagement, chatbots' responses to crisis situations, and considerations for chatbot-based therapy. In the use of Multitheoretical List of Therapeutic Interventions codes, we found that therapists evoked more elaboration (Mann-Whitney U=9; P=.001) and used more self-disclosure (U=45.5; P=.37) as compared to the chatbots. The chatbots used affirming (U=28; P=.045) and reassuring (U=23; P=.02) language more often than the therapists. The chatbots also used psychoeducation (U=22.5; P=.02) and suggestions (U=12.5; P=.003) more often than the therapists.
conclusionsOur study demonstrates the unsuitability of general-purpose chatbots to safely engage in mental health conversations, particularly in crisis situations. While chatbots display elements of good therapy, such as validation and reassurance, overuse of directive advice without sufficient inquiry and use of generic interventions make them unsuitable as therapeutic agents. Careful research and evaluation will be necessary to determine the impact of chatbot interactions and to identify the most appropriate use cases related to mental health.
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