Evidence map›Paper›PMID 40397919›Full record

ArticlePloS one2025

Metabolic and immune heterogeneity in stroke: Insights into subtype identification and biomarker discovery.

Wei Wang, Qiuyang Qian, Ziye Guo, Fangyi Lin, Weiming Lin, Zhigang Yuan, Mei Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei WangRehabilitation Medicine Department, Shenzhen Longhua District People's Hospital, Shenzhen, China.
Qiuyang QianRehabilitation Medicine Department, Shenzhen Longhua District People's Hospital, Shenzhen, China.
Ziye GuoDepartment of Critical Care Medicine, Shenzhen Longhua District People's Hospital, Shenzhen, China.
Fangyi LinRehabilitation Medicine Department, Shenzhen Longhua District People's Hospital, Shenzhen, China.
Weiming LinRehabilitation Medicine Department, Shenzhen Longhua District People's Hospital, Shenzhen, China.
Zhigang YuanRehabilitation Medicine Department, Shenzhen Longhua District People's Hospital, Shenzhen, China.
Mei ShenRehabilitation Medicine Department, Shenzhen Longhua District People's Hospital, Shenzhen, China.ORCID https://orcid.org/0000-0002-4339-9213

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke is a leading cause of mortality and long-term disability worldwide, characterized by substantial molecular and clinical heterogeneity. This study aimed to investigate the metabolic and immune-related mechanisms underlying stroke subtypes using transcriptomic data and advanced computational tools. Gene expression data from two GEO datasets (GSE16561 and GSE58294) were preprocessed, batch-corrected, and integrated. Consensus clustering based on 2,752 metabolism-related genes identified three distinct subtypes with significant differences in metabolic activity. GSVA analysis revealed subtype-specific variations in key pathways, such as the citrate cycle, glycolysis, and glycosaminoglycan biosynthesis, highlighting their metabolic diversity.

Indexed as

BiomarkersStrokeCluster AnalysisDatabases, GeneticGene Expression ProfilingGlycolysisHumansTranscriptomeBiomarkers

Identifiers

PMID40397919
PMCPMC12094752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.