ArticleRetina (Philadelphia, Pa.)2025
Fibrin Glue-Assisted Pretreated Lyophilized Human Amniotic Membrane Technique for Retinal Detachment With Inferior Retinal Break.
Article in Retina (Philadelphia, Pa.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Storage and Stability of AAV-Containing Fibrin Hydrogels for Retinal Gene Therapy.Gels (Basel, Switzerland) · 2026Article
- Degradable fibrin hydrogels for transplantation of iPSC-derived retinal pigment epithelial cell monolayers.Frontiers in cell and developmental biology · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
purposeTo investigate the effect and safety of fibrin glue-assisted pretreated lyophilized human amniotic membrane for retinal detachment caused by inferior retinal breaks.
methodsThe retinal breaks were sealed with intraocular photocoagulation after the retina was reattached. The lyophilized human amniotic membrane grafts were soaked in hypertonic glucose solution, followed by immersion in fibrin glue A (pretreatment), then dipped into the perfluorocarbon liquid and used to cover the breaks, perfluorocarbon liquid implanted under the breaks. Finally, the edge of the breaks and grafts were covered with fibrin glue B.
resultsRetinal reattachment was successful in all cases, and the median best-corrected visual acuity improved from 20/130 (Snellen) to 20/30 (Snellen) at the last visit. Lyophilized human amniotic membrane graft was displaced by fibrin contraction in one case after surgery, while the fibrin glue and grafts were stabilized in the other five cases. A little fibrin glue residue was detected in the macula area of 2 cases. One patient developed mild uveitis at 5 months after surgery but recovered after treatment.
conclusionThe fibrin glue-assisted pretreated lyophilized human amniotic membrane can achieve anatomical retinal reattachment for retinal detachment caused by inferior retinal breaks. Besides, this method can avoid intraocular tamponade of silicone oil and does not require postoperative position.
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