ArticlePloS one2025
High SRD5A3 expression is correlated with promotion of proliferation and inhibition of apoptosis in B-cell non-Hodgkin lymphoma and suggests a poor prognosis.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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8 authors.
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Abstract
backgroundSteroid 5α-reductase 3 (SRD5A3) is an important molecule involved in glycosylation and steroid hormone formation and is highly expressed in most tumors. However, The role of SRD5A3 in B-cell non-Hodgkin lymphoma (B-NHL) and its mechanism are unknown.
methodsWe used a multi-omics database to explore the expression and prognostic significance of SRD5A3 in various tumors, including B-NHL. We established SRD5A3 high- and low-expression B-NHL cell lines to test the effects of SRD5A3 on cell proliferation and apoptosis in vitro, and to analyze the signaling pathways associated with the effects of SRD5A3 on B-NHL.
resultsWe found that SRD5A3 was highly expressed in most tumors, including B-NHL, and was more highly expressed in patients age ≥60 years, high levels of LDH, stage III-IV, non-GCB subtype, and extra-nodal invasion. Survival analysis showed that high SRD5A3 expression predicted poorer overall survival (OS). Further experiments showed that SRD5A3 high expression promoted B-NHL growth and attenuates apoptosis, conversely, SRD5A3 low expression inhibited B-NHL growth and promoted apoptosis. Western blot assay showed SRD5A3 promotes B-NHL cells growth by regulating the PI3K-AKT signaling pathway.
conclusionsOur findings suggest that SRD5A3 exerts its oncogenic effects by regulating the PI3K-AKT pathway, may serve as a potential biomarker and therapeutic target for B-NHL, providing information for clinical decision-making.
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