Evidence map›Paper›PMID 40397753›Full record

ArticleScience advances2025

When less is more: Counterintuitive stoichiometries and cellular abundances are essential for ABC transporters' function.

Hiba Qasem Abdullah, Nurit Livnat Levanon, Michal Perach, Moti Grupper, Tamar Ziv, Oded Lewinson

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PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hiba Qasem AbdullahDepartment of Molecular Microbiology, Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.ORCID 0009-0001-5900-620X
Nurit Livnat LevanonDepartment of Molecular Microbiology, Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.ORCID 0000-0002-7153-4021
Michal PerachDepartment of Molecular Microbiology, Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Moti GrupperInfectious Disease Unit, Rambam Health Care Campus, Haifa, Israel.
Tamar ZivSmoler Proteomics Center, Technion-Israel Institute of Technology, Haifa, Israel.
Oded LewinsonDepartment of Molecular Microbiology, Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.ORCID 0000-0003-4650-0441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prokaryotes acquire essential nutrients primarily through adenosine triphosphate-binding cassette (ABC) importers, consisting of an adenosine triphosphatase, a permease, and a substrate-binding protein. These importers are highly underrepresented in proteomic databases, limiting our knowledge about their cellular copy numbers, component stoichiometry, and the mechanistic implications of these parameters. We developed a tailored proteomic approach to compile the most comprehensive dataset to date of the

Indexed as

ATP-Binding Cassette TransportersEscherichia coliEscherichia coli ProteinsBiological TransportProtein BindingProteomicsATP-Binding Cassette TransportersEscherichia coli Proteins

Identifiers

PMID40397753
PMCPMC12094219

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.