ArticleScience advances2025
Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Multisensory coding of audiovisual movies in the human hippocampus.bioRxiv : the preprint server for biology · 2026Article
- Rapid computation of high-level visual surprise.iScience · 2025Article
- Functional imaging of hippocampal layers using VASO and BOLD on the Next Generation (NexGen) 7T Scanner.bioRxiv : the preprint server for biology · 2025Article
- RDoC Framework Through the Lens of Predictive Processing: Focusing on Cognitive Systems Domain.Computational psychiatry (Cambridge, Mass.) · 2024Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current evidence suggests that the hippocampus is essential for exploiting predictive relationships during perception. However, it remains unclear whether the hippocampus drives the communication of predictions to sensory cortex or receives prediction signals from elsewhere. We collected 7-tesla fMRI data in the medial temporal lobe (MTL) while auditory cues predicted abstract shapes. Strikingly, neural patterns evoked by predicted shapes in CA2/3, pre/parasubiculum, and the parahippocampal cortex (PHC) were negatively correlated to patterns evoked by the same shapes when actually presented. Using layer-specific analyses, we ask: In which direction are predictions communicated between the hippocampus and neocortex? Superficial layers of the MTL cortex project to the hippocampus, while the deep layers receive feedback projections. Informational connectivity analyses revealed that communication between CA2/3 and PHC was specific to the deep layers of PHC. These findings suggest that the hippocampus generates predictions through pattern completion in CA2/3 and feeds these predictions back to the neocortex.
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