Evidence map›Paper›PMID 40397730›Full record

ArticleScience advances2025

CD8

Phillip Schiele, Alberto Sada Japp, Regina Stark, Joanna J Sattelberg, Christos Nikolaou, Gereon Kornhuber, Parya Abbasi, Nina Ding, Stanislav Rosnev, Stefan Meinke and 16 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. SATB1 preserves CD4Life science alliance · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Phillip SchieleTherapy-Induced Remodeling in Immuno-Oncology, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0002-2342-3597
Alberto Sada JappRegenerative Immunology and Aging, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0001-8106-8987
Regina StarkRegenerative Immunology and Aging, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0001-7693-799X
Joanna J SattelbergMax-Delbrück-Center for Molecular Medicine and Institute for Immunology, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Christos NikolaouRegenerative Immunology and Aging, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0001-6018-3564
Gereon KornhuberTherapy-Induced Remodeling in Immuno-Oncology, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0009-0001-8222-9372
Parya AbbasiTherapy-Induced Remodeling in Immuno-Oncology, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0009-0004-7768-5439
Nina DingTherapy-Induced Remodeling in Immuno-Oncology, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0009-0002-2324-1977
Stanislav RosnevTherapy-Induced Remodeling in Immuno-Oncology, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0003-0256-7038
Stefan MeinkeRegenerative Immunology and Aging, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0001-5083-3383
Kerstin MühleRegenerative Immunology and Aging, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
Lucie LoyalRegenerative Immunology and Aging, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0001-5738-4437
Julian BraunRegenerative Immunology and Aging, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0002-7788-8154
Manuela DingeldeyRegenerative Immunology and Aging, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0001-8412-3910
Sibel DurlanikRegenerative Immunology and Aging, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
Nadine MatzmohrRegenerative Immunology and Aging, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
Donata Ponikwicka-TyszkoInstitute of Biomedicine, University of Turku, 20520 Turku, Finland.
Slawomir WolczynskiDepartment of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, 15-276 Bialystok, Poland.ORCID 0000-0002-7806-1394
Nafis A RahmanInstitute of Biomedicine, University of Turku, 20520 Turku, Finland.ORCID 0000-0001-5257-870X
Ichiro TaniuchiRIKEN Research Center for Allergy and Immunology, Yokohama 230-0045, Japan.ORCID 0000-0002-9853-9068
Stephan SchlickeiserInstitute for Medical Immunology, Charité-Universitätsmedizin Berlin, Corporate members of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-3142-2890
Claudia Giesecke-ThielMax Planck Institute for Molecular Genetics, 14195 Berlin, Germany.ORCID 0000-0002-5927-7018
Thomas BlankensteinMax-Delbrück-Center for Molecular Medicine and Institute for Immunology, Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Il-Kang NaTherapy-Induced Remodeling in Immuno-Oncology, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0001-9902-5424
Andreas ThielRegenerative Immunology and Aging, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0002-5515-4002
Marco FrentschTherapy-Induced Remodeling in Immuno-Oncology, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0003-3200-210X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cells and their effector functions, in particular the canonical cytotoxicity of CD8

Indexed as

CD40 AntigensCD40 LigandCD8-Positive T-LymphocytesCytotoxicity, ImmunologicNeoplasmsAnimalsCaspase 8Cell Line, TumorHumansMiceSignal TransductionCaspase 8CD40 AntigensCD40 Ligand

Identifiers

PMID40397730
PMCPMC12094236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.