Evidence map›Paper›PMID 40397675›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Mechanisms of photoreceptor protection upon targeting the

Daniel P Murphy, Alexander V Kolesnikov, Cynthia L Montana, Zaid M Khaja, Yu Liu, Vladimir J Kefalov, Joseph C Corbo

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel P MurphyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-4846-4608
Alexander V KolesnikovGavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, CA 92617.
Cynthia L MontanaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Zaid M KhajaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0009-0001-0101-1399
Yu LiuDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Vladimir J KefalovGavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, CA 92617.ORCID 0000-0002-1659-008X
Joseph C CorboDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-9323-7140

Funding

NEI UCI Center Core Grant for Vision ResearchP30EY034070 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Rachel Wagner Martin · 2022 to 2026
$3.7M
Elucidating the cis-regulatory grammar of human photoreceptorsR01EY030075 · NEI · WASHINGTON UNIVERSITY · PI CORBO, JOSEPH · 2020 to 2023
$2.2M
Targeting Nr2e3 to prevent photoreceptor degenerationR01EY033810 · NEI · WASHINGTON UNIVERSITY · PI JOSEPH CORBO, Vladimir Jivkov Kefalov · 2023 to 2026
$2.0M
HHS | NIH (NIH) EY030075HHS | NIH (NIH) EY033810NEI NIH HHS P30 EY034070NEI NIH HHS R01 EY030075NEI NIH HHS R01 EY033810Washington University's Hope Center for Neurological Disorders N/A
6 · The paper itself

Abstract

Acute knockout of the rod photoreceptor transcription factor

Indexed as

Basic-Leucine Zipper Transcription FactorsEye ProteinsOrphan Nuclear ReceptorsRetinal DegenerationRetinal Rod Photoreceptor CellsAnimalsCyclic Nucleotide Phosphodiesterases, Type 6MiceMice, KnockoutRetinal Cone Photoreceptor CellsRhodopsinSignal TransductionBasic-Leucine Zipper Transcription FactorsCyclic Nucleotide Phosphodiesterases, Type 6Eye ProteinsNr2e3 protein, mouseNrl protein, mouseOrphan Nuclear ReceptorsRhodopsinNr2e3Nrlphotoreceptorretinaretinitis pigmentosa

Identifiers

PMID40397675
PMCPMC12130857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.