Evidence map›Paper›PMID 40397671›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Calcineurin controls the cytokinesis machinery during thermal stress in

Vikas Yadav, Anna Floyd Averette, Rajendra Upadhya, Joseph Heitman

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Whole-chromosome duplications drive antimicrobial resistance inbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Calcineurin targets that mediateProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Vikas YadavDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0003-2650-9035
Anna Floyd AveretteDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-5877-0812
Rajendra UpadhyaDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0001-6369-5995

Funding

Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
Calcineurin signaling cascades governing Cryptococcus virulenceR01AI172451 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN · 2023 to 2026
$2.7M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI039115-27HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI050113-20HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI172451-02NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R01 AI172451NIAID NIH HHS R37 AI039115
6 · The paper itself

Abstract

Calcineurin is a highly conserved phosphatase that plays a central role in sensing calcium and governing transcriptional, posttranscriptional, and posttranslational signaling networks. Calcineurin is a heterodimer consisting of a catalytic A subunit and a regulatory B subunit. Through downstream effectors, calcineurin signaling drives myriad responses in different organisms. In the fungal pathogenic

Indexed as

CalcineurinCryptococcusCytokinesisFungal ProteinsHeat-Shock ResponseSignal TransductionCalcineurinFungal Proteinsbuddingchitin synthasesgenetic suppressioningression progression complexmitotic exit

Identifiers

PMID40397671
PMCPMC12130876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.