ArticleIEEE transactions on bio-medical engineering2025
High-Resolution Brain Metabolic Imaging at Ultrahigh Field Using Extended Spatiospectral Encoding and Subspace Modeling.
Article in IEEE transactions on bio-medical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Mitochondrial dysfunction in Alzheimer's disease: connecting pathophysiology with neuroimaging.Frontiers in aging neuroscience · 2026Review
- Study protocol for the Champaign-Urbana population study.Frontiers in neuroimaging · 2026Article
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Authors and funding
15 authors.
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Abstract
objectiveTo develop a high-resolution magnetic resonance (MR) metabolic imaging method for mapping human brain metabolite distributions at ultrahigh field (7T).
methodsIn data acquisition, a free-induction-decay (FID) based MR spectroscopic imaging (MRSI) sequence was implemented. To achieve high spatial resolution, the sequence used fast echo-planar spectroscopic imaging (EPSI) trajectories with echo-spacings larger than the Nyquist sampling interval. Using this sequence, 3D MRSI signals at isotropic nominal resolutions of 3.0 mm and 1.8 mm were acquired within scan times of 4.8 and 14.2 minutes, respectively. In data processing, model-based methods integrating subspace learning, spectral modeling, and generalized series modeling were developed to address key challenges, including spectral ghosting, low signal-to-noise ratio, and spectral aliasing.
resultsThe proposed acquisition and processing methods successfully generated high-resolution, high-quality metabolite maps of the human brain at 7T. Experimental results from phantom and in vivo scans validated the proposed method and showed its capability to capture detailed brain metabolite distributions.
conclusionThis work demonstrates the feasibility of high-resolution brain metabolic imaging at ultrahigh field using MRSI acquisition sequence and model-based processing methods. SIGNIFICANCE: By providing high-resolution spatial mapping of brain metabolites within clinically feasible scan times, the proposed method promises to offer a powerful imaging tool for investigating brain metabolism, which is expected to be useful for various brain imaging applications.
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