Evidence map›Paper›PMID 40397617›Full record

ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2025

Automated movement analysis predicts transition to non-psychotic disorders in individuals at ultra-high risk for psychosis.

Ana Caroline Lopes-Rocha, Cheryl Mary Corcoran, Felipe Argolo, Andrea Fontes Jafet, Anderson Ara, João Medrado Gondim, Natalia Mansur Haddad, Leonardo Peroni de Jesus, Mauricio Henriques Serpa, Martinus Theodorus van de Bilt and 3 more

Abstract read
In one paragraph

Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ana Caroline Lopes-RochaLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Cheryl Mary CorcoranDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Felipe ArgoloLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Andrea Fontes JafetLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Anderson AraDepartamento de Estatística, Universidade Federal do Paraná, Curitiba, PR, Brazil.
João Medrado GondimInstituto de Computação, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Natalia Mansur HaddadLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Leonardo Peroni de JesusLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Mauricio Henriques SerpaLaboratório de Neuroimagem em Psiquiatria (LIM 21), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, SP, Brazil.
Martinus Theodorus van de BiltLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil. Instituto Nacional de Biomarcadores em Neuropsiquiatria, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil.
Wagner Farid GattazLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil. Instituto Nacional de Biomarcadores em Neuropsiquiatria, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil.
Guillermo CecchiIBM Thomas J. Watson Research Center, Yorktown Heights, NY, USA.
Alexandre Andrade LochLaboratório de Neurociências (LIM 27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil. Instituto Nacional de Biomarcadores em Neuropsiquiatria, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 565412/2014-9Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.625326/2021-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/50873-3Wellcome TrustWellcome Trust 223139/Z/21/Z
6 · The paper itself

Abstract

objectiveUltra-high risk criteria were developed to identify prodromal symptoms of psychosis, although the transition does not occur in most individuals. This highlights the need to identify transition markers, such as movement analysis. In the first stage of our study, movement analysis was used to differentiate controls from ultra-high risk patients, who had reduced movement and increased erraticism. We aimed to determine whether these variables can predict ultra-high risk outcomes after follow-up.

methodsUltra-high risk individuals were recorded while performing two speech tasks at baseline. The videos were analyzed using motion energy analysis for head and torso movements (mean amplitude, frequency, and variability) and were manually coded for gesticulation. During follow-up, seven participants transitioned to psychosis, 21 to other DSM-5 disorders (called the general disorder group), and 18 did not transition to psychosis.

resultsThe general disorders group showed lower torso frequency and higher variability in both regions than the psychosis group, as well as greater torso variability than the non-transition group. No differences were found between the psychosis and non-transition groups. Gesticulation did not significantly differ between groups.

conclusionsBaseline movement variability distinguishes ultra-high risk transition outcomes, with higher variability in those who transitioned to non-psychotic disorders. This demonstrates the importance of movement analysis as a potential transition marker and suggests that treating ultra-high risk individuals as a single group may overlook important information.

Indexed as

Prodromal SymptomsPsychotic DisordersAdolescentAdultCase-Control StudiesDisease ProgressionFemaleHumansMaleMovementPredictive Value of TestsRisk FactorsVideo RecordingYoung Adultgesturesmotion energy analysismovement analysistransition markersUltra-high risk

Identifiers

PMID40397617
PMCPMC12815393

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.