Evidence map›Paper›PMID 40397482›Full record

ReviewInflammatory bowel diseases2025

Unravelling the Relationship Between Obesity and Inflammatory Bowel Disease.

Jessica Sun, Ella C Brooks, Yashar Houshyar, Susan J Connor, Gokulan Paven, Michael C Grimm, Georgina L Hold

Abstract readReview
In one paragraph

Review in Inflammatory bowel diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jessica SunMicrobiome Research Centre, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Ella C BrooksMicrobiome Research Centre, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Yashar HoushyarMicrobiome Research Centre, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Susan J ConnorDepartment of Gastroenterology and Hepatology, Liverpool Hospital, Liverpool, NSW 2170, Australia.
Gokulan PavenSt. George and Sutherland Clinical Campuses, University of New South Wales, Sydney, NSW, Australia.
Michael C GrimmMicrobiome Research Centre, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Georgina L HoldMicrobiome Research Centre, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0001-7573-3397

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mirroring the global obesity epidemic, obesity rates in inflammatory bowel disease (IBD) patients is rising. Several epidemiological studies propose that 15%-40% of adult patients with IBD are obese, and an additional 25%-40% fall into the overweight category. This article examines the pathophysiologic relationship between obesity and IBD concerning the role of visceral adipose tissue, microbiota shifts, dietary patterns, and hunger hormone changes. Additionally, increasing evidence is demonstrating the negative impact that obesity is having on disease course and quality of life in patients with IBD. Obesity has been demonstrated to be associated with an attenuated response to immunomodulators and biological agents, as well as higher rates of peri-operative surgical complications. A better understanding of the relationship between obesity and IBD can be applied to clinical decision-making in personalizing treatment plans, promoting weight loss in patients with obesity, and identifying areas of future research.

Indexed as

Inflammatory Bowel DiseasesObesityGastrointestinal MicrobiomeHumansQuality of Lifebody mass indexCrohn’s diseaseinflammatory bowel diseaseobesityulcerative colitis

Identifiers

PMID40397482
PMCPMC12455606

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.