Evidence map›Paper›PMID 40397461›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Spectroscopic Interrogation of Thiolate Hydrogen Bonding in the CO Sensor Protein CooA: Implications for Thiolate Ligation Stability and Cytochrome P450 Function.

Brian R Weaver, Richard J Jodts, Brian M Hoffman, Joshua Telser, Judith N Burstyn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brian R WeaverDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Richard J JodtsDepartments of Chemistry and Molecular Biosciences, Northwestern University, Evanston, IL, 60208, USA.
Brian M HoffmanDepartments of Chemistry and Molecular Biosciences, Northwestern University, Evanston, IL, 60208, USA.ORCID https://orcid.org/0000-0002-3100-0746
Joshua TelserDepartment of Biological, Physical, and Health Sciences, Roosevelt University, Chicago, IL, 60605, USA.ORCID https://orcid.org/0000-0003-3307-2556
Judith N BurstynDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID https://orcid.org/0000-0003-3245-5563

Funding

Coboglobins-Cobalt-Substituted Hemoglobins and MyoglobinR01GM111097 · NIGMS · NORTHWESTERN UNIVERSITY · PI HOFFMAN, BRIAN M · 2014 to 2025
$6.7M
Molecular Biophysics Training Program at Northwestern UniversityT32GM008382 · NIGMS · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 1990 to 2020
$4.3M
Irving Shain Chair of ChemistryNational Science Foundation CHE-2333907National Science Foundation DGE-1747503NIGMS NIH HHS R01 GM111097NIGMS NIH HHS T32 GM008382NIH HHS GM111097NSF-GRFP DGE-1747503
6 · The paper itself

Abstract

Cysteine (Cys) thiolate coordination in hemoproteins is a unique ligation motif found in enzymes and small molecule sensors. It is posited that divergence between these two functional classes of heme thiolate proteins is a result of distinct hydrogen bonding (H-bonding) interactions with the axial Cys(thiolate) ligand. To further test this hypothesis, we report a spectroscopic analysis of thiolate H-bonding in CooA, a carbon monoxide-sensing heme protein from Rhodospirillum rubrum that is known to switch between Cys

Indexed as

Bacterial ProteinsCarbon MonoxideCysteineCytochrome P-450 Enzyme SystemHemeproteinsRhodospirillum rubrumSulfhydryl CompoundsElectron Spin Resonance SpectroscopyHistidineHydrogen BondingLigandsBacterial ProteinsCarbon MonoxideCysteineCytochrome P-450 Enzyme SystemHemeproteinsHistidineLigandsSulfhydryl CompoundsCOEPRhememagnetic resonancesensors

Identifiers

PMID40397461
PMCPMC12223480

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.