Evidence map›Paper›PMID 40397371›Full record

ArticleAIDS and behavior2025

Preference for Service Delivery for Long-Acting Pre-exposure Prophylaxis for HIV Infection Among Pregnant and Breastfeeding Women in South Africa and Botswana.

Lindsey de Vos, Aamirah Mussa, Elzette Rousseau, Michael Strauss, Gavin George, Prisca Vundhla, Avuyonke Gebengu, Maipelo Tsuaneng, Lefhela Tamuthiba, Aratwa Tumagole and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lindsey de Vos *Research Unit, Foundation for Professional Development, East London, South Africa.
Aamirah MussaBotswana Harvard Health Partnership, Gaborone, Botswana.
Elzette RousseauDesmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Michael StraussHealth Economics and HIV and AIDS Research Division (HEARD), University of KwaZulu-Natal, Durban, South Africa.
Gavin GeorgeHealth Economics and HIV and AIDS Research Division (HEARD), University of KwaZulu-Natal, Durban, South Africa.
Prisca VundhlaDesmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Avuyonke GebenguResearch Unit, Foundation for Professional Development, East London, South Africa.
Maipelo TsuanengBotswana Harvard Health Partnership, Gaborone, Botswana.
Lefhela TamuthibaBotswana Harvard Health Partnership, Gaborone, Botswana.
Aratwa TumagoleBotswana Harvard Health Partnership, Gaborone, Botswana.
Neo MoshashaneBotswana Harvard Health Partnership, Gaborone, Botswana.
Chelsea MorroniBotswana Harvard Health Partnership, Gaborone, Botswana.
Remco P H PetersResearch Unit, Foundation for Professional Development, East London, South Africa.
Chibuzor M BabalolaDepartment of Population and Public Health Science, University of Southern California, Los Angeles, CA, USA.
Jeffrey D KlausnerDepartment of Population and Public Health Science, University of Southern California, Los Angeles, CA, USA.
Dvora Joseph Davey *Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa. djosephdavey@mednet.ucla.edu.

Funding

Stepped care to optimize PrEP effectiveness in pregnant and postpartum women (SCOPE-PP) in South AfricaR01HD106862 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DVORA Leah JOSEPH DAVEY · 2021 to 2026
$2.7M
A community-based adaptation of a peer-led intervention to address alcohol use and HIV risk in pregnant women in South Africa (Mentor Moms+)R34AA030942 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Zaynab Essack, DVORA Leah JOSEPH DAVEY · 2024 to 2026
$524k
Merck Investigator Initiated Studies Program (MISP) Merck Investigator Initiated Studies Program (MISP)NIAAA NIH HHS R34 AA030942NICHD NIH HHS R01 HD106862
6 · The paper itself

Abstract

HIV particularly affects women during pregnancy and postpartum, where they face a two-fold or more increased risk of HIV acquisition. We explored preferences for long-acting PrEP and multipurpose prevention technologies among pregnant and breastfeeding women (PBFW) without HIV. From April to December 2023, we conducted a discrete choice experiment at maternal healthcare clinics in Cape Town, East London (South Africa), and Gaborone (Botswana) including PrEP-experienced and PrEP-naive women. Analysis included site stratification, mixed-effects logistic regression, and latent class modeling. Among 450 pregnant and breastfeeding women (52% pregnant, 47% breastfeeding), vaginally inserted and implanted PrEP was least preferred compared to oral. East London and Gaborone preferred clinic PrEP pick-up and effectiveness, while Cape Town showed indifference for community delivery. Three latent classes emerged: 'comprehensive delivery seekers' (43%), 'physical and physiological prioritisers' (25%), and 'vaginal insertion avoiders' (32%). Future PrEP programs should prioritize user-centered approaches, aligning with user preferences for effective use.

Indexed as

Anti-HIV AgentsBreast FeedingHIV InfectionsPatient PreferencePre-Exposure ProphylaxisPregnancy Complications, InfectiousPregnant PeopleAdultBotswanaFemaleHumansInfectious Disease Transmission, VerticalPregnancySouth AfricaYoung AdultAnti-HIV AgentsAfricaDiscrete choice experimentPostpartumPregnantPrEPWomen

Identifiers

PMID40397371
PMCPMC12432069

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.