Evidence map›Paper›PMID 40397370›Full record

ArticleTissue engineering and regenerative medicine2025

Feasibility Assessment of 3D Printing-Based Tubular Tissue Flap in a Porcine Model for Long Segmental Tracheal Reconstruction.

Jeong Hun Park, Nettie E Brown, Sarah Jo Tucker, Johnna S Temenoff, Mark El-Deiry, Hyun-Ji Park, Andrew T Tkaczuk, Scott J Hollister

Abstract read
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In one paragraph

Article in Tissue engineering and regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Cell-Cell or Cell-Biomaterial Interactions for Therapeutic Application.Tissue engineering and regenerative medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jeong Hun Park *Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA, 30332, USA.
Nettie E Brown *Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA, 30332, USA.
Sarah Jo TuckerGlobal Center for Medical Innovation, 575 14th Street, Atlanta, GA, 30318, USA.
Johnna S TemenoffWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA, 30332, USA.
Mark El-DeiryDepartment of Otolaryngology Head and Neck Surgery, Emory University School of Medicine, 550 Peachtree Street NE, Atlanta, GA, 30308, USA.
Hyun-Ji ParkDepartment of Molecular Science and Technology, Ajou University, 206 Worldcup-Ro, Suwon, 16499, Republic of Korea.
Andrew T TkaczukDepartment of Otolaryngology Head and Neck Surgery, Emory University School of Medicine, 550 Peachtree Street NE, Atlanta, GA, 30308, USA. andrew.thomas.tkaczuk@emory.edu.
Scott J HollisterWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA, 30332, USA. scott.hollister@bme.gatech.edu.ORCID http://orcid.org/0000-0001-7625-892X

Funding

National Institute of Child Health and Human Development R01 086201
6 · The paper itself

Abstract

backgroundDespite advances in tissue engineering, current clinical reconstructive options for long segment tracheal defects are limited. In this study, a 3D printing based tubular tissue flap strategy was developed for long segment tracheal reconstruction.

methodA stent-patterned airway scaffold with sufficient radial rigidity and longitudinal bending flexibility was designed and its mechanical behavior was analyzed using finite element analysis (FEA). The stent-patterned airway scaffolds with a removable central core to preserve an internal lumen were created by selective laser sintering (SLS) based 3D printing. The stent-patterned airway scaffold with the central core, filled with poly (ethylene glycol) diacrylate-dithiothreitol (PEGDA-DTT) hydrogel containing erythropoietin (EPO) to enhance vascularization, was then implanted into the latissimus dorsi muscle of a Yucatan minipig.

resultsA tubular tissue flap, with controlled luminal layer thickness was successfully created by removing the central core from the retrieved tissue flap containing the airway scaffold after 45 days of implantation in the Yucatan minipig model.

conclusionThe current work validated the potential of the tubular tissue flap based on the 3D printing as a clinically viable tissue engineering strategy for long segment tracheal reconstruction.

Indexed as

Plastic Surgery ProceduresPrinting, Three-DimensionalSurgical FlapsTissue EngineeringTracheaAnimalsFeasibility StudiesFinite Element AnalysisSwineSwine, MiniatureTissue Scaffolds3D printingFlap reconstructionSelective laser sinteringTracheal reconstructionVascularization

Identifiers

PMID40397370
PMCPMC12122989

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.