Evidence map›Paper›PMID 40397348›Full record

ArticleThe international journal of cardiovascular imaging2025

Right and left ventricular filling in adult patients with repaired tetralogy of fallot: a 4D flow MRI study.

Gabrielle Marcilhacy, Damian Craiem, Mariano E Casciaro, Umit Gencer, Sophie Malekzadeh Milani, Antoine Legendre, Laurence Iserin, Elie Mousseaux, Gilles Soulat

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Article in The international journal of cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Gabrielle MarcilhacyUniversité Paris Cité, Inserm, PARCC, Paris, F-75015, France.
Damian CraiemTrasplante y Bioingeniería (IMeTTyB), Instituto de Medicina Traslacional, Universidad Favaloro-CONICET, Buenos Aires, Argentina.
Mariano E CasciaroTrasplante y Bioingeniería (IMeTTyB), Instituto de Medicina Traslacional, Universidad Favaloro-CONICET, Buenos Aires, Argentina.
Umit GencerUniversité Paris Cité, Inserm, PARCC, Paris, F-75015, France.
Sophie Malekzadeh MilaniPublique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20 rue leblanc, Paris, 75015, France.
Antoine LegendrePublique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20 rue leblanc, Paris, 75015, France.
Laurence IserinPublique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20 rue leblanc, Paris, 75015, France.
Elie MousseauxUniversité Paris Cité, Inserm, PARCC, Paris, F-75015, France.
Gilles SoulatUniversité Paris Cité, Inserm, PARCC, Paris, F-75015, France. gilles.soulat@aphp.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In repaired Tetralogy of Fallot (TOF), RV replacement fibrosis is a predictor of hard events, but diastolic dysfunction, which should be related to ventricular fibrosis, is not part of the management process. 4D flow MRI may provide new insights about ventricular filling in repaired TOF. This study evaluates the relationship between RV and LV diastolic function and indicators of hemodynamic, exercise function and late gadolinium enhancement (LGE) in adults with repaired TOF. 41 TOF patients (22 male, mean age 38 ± 11 y) were retrospectively studied and compared with 21 controls. Early peak filling rate (PFR), atrial peak filling rate (PAFR) and filling volume (FV) were extracted from 4D flow for right (RV) and left (LV) ventricles. For the RV both tricuspid inflow and the whole RV filling (summing tricuspid inflow, and pulmonary regurgitation) were considered. Mitral and RV PFR/PAFR were significantly higher in TOF than in controls (2.59 [1.62-3.86] vs. 1.52 [1.20-2.07]; p < 0,001 and 2.06 [1.38-3.53] vs. 1.2 [0.88-1.53]; p < 0.001). Mitral PFR/PAFR ratio was decreased in patient with VO2 peak < 23 mL.kg.min (3.28[2.40-3.88] vs. 1.75 [1.18-3.07,p = 0.027). RV PFR/PAFR was decreased in patient with severe junctional LGE (PFR/PAFR of 2.61 [2.11-3.75 vs. 2.19 [1.62-3.7] vs. 1.33 [1.02-1.67], in none to minimal, mild to moderate and severe LGE groups respectively, p = 0.011). LV diastolic function was impaired in case of decreased exercise performance and RV impaired relaxation was more prevalent in case of junctional LGE.

Indexed as

Cardiac Surgical ProceduresMagnetic Resonance Imaging, CineMyocardial Perfusion ImagingTetralogy of FallotVentricular Dysfunction, LeftVentricular Dysfunction, RightVentricular Function, LeftVentricular Function, RightAdultCase-Control StudiesContrast MediaExercise TestExercise ToleranceFemaleFibrosisHemodynamicsContrast Media4D flowCongenital heart diseaseDiastolic functionTetralogy of fallot

Identifiers

PMID40397348

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.