ArticleDiscover nano2025
Light modulates plant-derived extracellular vesicle properties: a photosensitive-responsive nanodelivery system.
Article in Discover nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Extracellular vesicles released by in vitro plant cell cultures: emerging systems for vesicle-mediated communication and biomedical translation.Plant cell reports · 2026Review
- Past, Present, and Future of Plant-Derived Extracellular Vesicles in Biomedical Applications.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Recent progress of plant-derived extracellular vesicle-like nanoparticles integrated with biomaterials for skin repair.Journal of nanobiotechnology · 2026Review
- From targeted delivery to inflammation suppression: engineering plant exosomes for heart failure therapy post-infarction.Materials today. Bio · 2026Article
- Engineering Strategies for Plant-Derived Extracellular Vesicles: Modification, Drug Delivery Performance, and Synergistic Effects with Gel Composite Systems.Pharmaceutics · 2026Review
- Plant-Derived Nanovesicles: A Comprehensive Review from Isolation to Clinical Translation-Unlocking Natural Nanocarriers for Biomedical Applications.Biomolecules · 2026Review
- Extracellular Vesicles Derived from Natural Biological Resources and Their Potential to Facilitate Skin Regeneration and Rejuvenation.Pharmaceutics · 2026Review
- Plant-derived extracellular vesicles for drug delivery: current and future.Regenerative biomaterials · 2026Review
- Research Progress and Preclinical Prospects of Plant-Derived Extracellular Vesicles in Targeted Delivery of Antitumor Drugs.International journal of nanomedicine · 2026Review
- Multidimensional Regulatory Mechanisms and Targeted Therapeutic Strategies for Inhibited Keratinocyte Proliferation in Diabetic Wounds.Drug design, development and therapy · 2026Review
- Oral plant-derived exosome-like nanovesicles: a new therapeutic perspective for intestinal diseases.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant-derived extracellular vesicles (PDEVs) have emerged as innovative nanocarriers for drug delivery, offering advantages such as biocompatibility, stability, and cost-effectiveness. This study explores light-mediated strategies to optimize cargo encapsulation into PDEVs while preserving structural integrity. Leveraging the intrinsic photosensitizing properties of PDEVs, light irradiation (LED) triggered reactive oxygen species (ROS) generation, including superoxide anions and singlet oxygen, which transiently enhanced membrane permeability for controlled drug loading. Using FITC-dextran (70 kDa) as a model cargo, we optimized light-induced loading efficiency, achieving a peak (~ 80%) at 10 min of irradiation. Prolonged exposure (15 min) reduced efficiency (~ 50%), likely due to excessive ROS-induced membrane destabilization. The optimal PDEVs-to-cargo ratio (1:30) ensured maximal loading while maintaining stability over 30 days. Lipid peroxidation analysis further confirmed ROS-induced membrane modifications through malondialdehyde (MDA) accumulation. These findings demonstrate that PLDENs (Pueraria lobate-derived exosomes-like nanovesicles) function as light-responsive nanocarriers, balancing ROS-mediated permeability enhancement with structural integrity. This light-triggered strategy balances permeability modulation and structural integrity, advancing PDEVs as scalable, non-invasive platforms for precision drug delivery and photodynamic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.