Evidence map›Paper›PMID 40397323›Full record

ArticleBreast cancer research and treatment2025

Social determinants of cardiovascular disease in women with and without breast cancer.

Elena Wadden, Vidhushei Yogeswaran, Roberta M Ray, Alexi Vasbinder, Aladdin H Shadyab, Qian Xiao, Phyllis A Richey, Nazmus Saquib, Yangbo Sun, Su Yon Jung and 8 more

Abstract read
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In one paragraph

Article in Breast cancer research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Elena WaddenDepartment of Medicine, University of Washington, Seattle, WA, USA.
Vidhushei YogeswaranDivision of Cardiology, University of Washington, Seattle, WA, USA.
Roberta M RayFred Hutchinson Cancer Center, Seattle, WA, USA.
Alexi VasbinderDepartment of Biobehavioral Nursing and Health Informatics, University of Washington School of Nursing, Seattle, WA, USA.
Aladdin H ShadyabHerbert Wertheim School of Public Health and Human Longevity Science and Division of Geriatrics, Gerontology, and Palliative Care, Department of Medicine, University of California, La Jolla, San Diego, CA, USA.
Qian XiaoDepartment of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, USA.
Phyllis A RicheyDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Nazmus SaquibCollege of Medicine, Sulaiman AlRajhi University, Al Bukayriyah, Saudi Arabia.
Yangbo SunDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Su Yon JungTranslational Sciences Section, School of Nursing, Department of Epidemiology, Fielding School of Public Health, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA.
Margaret S PichardoDepartment of Surgery, Hospital of the University of Pennsylvania, Penn Medicine, Philadelphia, PA, USA.
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Garnet AndersonFred Hutchinson Cancer Center, Seattle, WA, USA.
Michael SimonKarmanos Cancer Institute, Detroit, MI, USA.
Marcia L StefanickDepartment of Medicine, Stanford University, Stanford, CA, USA.
Kerryn RedingDepartment of Biobehavioral Nursing and Health Informatics, University of Washington School of Nursing, Seattle, WA, USA.
Ana BaracInova Schar Heart and Vascular Institute, Fairfax Falls Church, VA, USA.
Richard K ChengDivision of Cardiology, University of Washington, Seattle, WA, USA. rkcheng@uw.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSocial determinants of health (SDOH) may impact cardiovascular (CV) risk in women with and without breast cancer (BC).

methodsIn 153,401 participants without prevalent CV disease from the Women's Health initiative (WHI), we assessed key SDOH factors: geographic region, rurality, insurance status, and household income. Multivariable Cox proportional hazards models were used to assess associations between SDOH factors and a composite CV outcome, which included incident myocardial infarction, incident stroke, hospitalization for heart failure, or CV death.

resultsIn the final cohort, 10,954 (mean ± standard deviation [SD] age 62 ± 7 years) women developed BC, and 142,144 (mean age 63 ± 7 years) women remained free of BC. During a median follow-up time of 13 years, 18,148 women experienced the composite CV outcome. Rurality, low household income, and non-private insurance were associated with an increased risk of the composite CV outcome and CV death, both in women with and without BC.

conclusionsSDOH factors are associated with an increased risk of CV events among women, irrespective of BC status. These associations highlight the importance of socioeconomic factors across cardiovascular health outcomes.

Indexed as

Breast NeoplasmsCardiovascular DiseasesSocial Determinants of HealthAgedFemaleHumansMiddle AgedProportional Hazards ModelsRisk FactorsSocioeconomic FactorsWomen's HealthBreast cancerCoronary artery diseaseEpidemiologyWomen’s oncology

Identifiers

PMID40397323

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.