Evidence map›Paper›PMID 40397319›Full record

ArticleJournal of neuro-oncology2025

Preoperative assessment of tumor eloquence and resectability: an international survey.

Emma Rammeloo, Jacob S Young, Joost W Schouten, Eelke M Bos, Shawn L Hervey-Jumper, Christine Jungk, Sandro M Krieg, Timothy Smith, Jordina Rincon-Torroella, Chetan Bettegowda and 9 more

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In one paragraph

Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Contemporary surgical strategies for resection of intracranial gliomas.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Emma RammelooDepartment of Neurosurgery, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. e.rammeloo@erasmusmc.nl.ORCID https://orcid.org/0009-0002-8932-2905
Jacob S YoungDepartment of Neurosurgery, University of California, San Francisco, CA, USA.
Joost W SchoutenDepartment of Neurosurgery, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Eelke M BosDepartment of Neurosurgery, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Shawn L Hervey-JumperDepartment of Neurosurgery, University of California, San Francisco, CA, USA.
Christine JungkDepartment of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
Sandro M KriegDepartment of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
Timothy SmithDepartment of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA.
Jordina Rincon-TorroellaDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Chetan BettegowdaDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Takashi MaruyamaDepartment of Neurosurgery, Tokyo University, Tokyo, Japan.
Arthur WagnerDepartment of Neurosurgery, Technical University Munich, Munich, Germany.
Philippe SchuchtDepartment of Neurosurgery, Inselspital University Hospital Bern, Bern, Switzerland.
Marike L D BroekmanDepartment of Neurosurgery, Haaglanden Medical Center, and Leiden University Medical School, The Hague, The Netherlands.
Steven De VleeschouwerDepartment of Neurosurgery, University Hospitals Leuven, Leuven, Belgium.
Brian V NahedDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
Mitchel S BergerDepartment of Neurosurgery, University of California, San Francisco, CA, USA.
Arnaud J P E Vincent *Department of Neurosurgery, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Jasper K W Gerritsen *Department of Neurosurgery, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.

Funding

UCSF Paul Calabresi K12 Career Development Program in Clinical OncologyK12CA260225 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BERGSLAND, EMILY K, BIVONA, TREVER G · 2021 to 2025
$2.6M
NCI NIH HHS K12 CA260225
6 · The paper itself

Abstract

BACKGROUND AND

objectivesTumor location and its proximity to eloquent brain areas are key factors in glioma surgery decision-making. However, the absence of a consensus definition for eloquent brain areas leads to variability in surgical decision-making. This survey aimed to assess this heterogeneity in defining eloquent brain regions.

methodsA survey was distributed among neurosurgeons in the United States, Europe, Latin America, and Australasia between February and November 2023. Respondents rated the eloquence of various brain structures on a Likert scale and reported their use of preoperative techniques. Twelve glioma and glioblastoma cases were presented to assess opinions on tumor location eloquence and preferred surgical approaches.

results157 neurosurgeons from 25 countries responded to the survey. Two-thirds (68%) agreed on the need for a standardized definition of eloquence, while only 23% applied existing eloquence grading scales. Eloquence ratings varied, with the highest variation reported for the corona radiata, uncinate fasciculus and superior longitudinal fasciculus. In patient cases, variability was observed at four levels of decision-making: (1) degree of eloquence; (2) preferred surgical modality; (3) use of intraoperative mapping; (4) the preferred mapping modality (asleep or awake).

conclusionsThis survey highlights the variability in defining eloquence and its impact on glioma surgery decision-making. This lack of consensus limits the reliability of eloquence as a descriptor of tumor location, affecting patient care and comparability across studies. Future research should focus on the development of an easy-to-use, objective method (based on intraoperative data) for identifying eloquent brain regions preoperatively.

Indexed as

Brain NeoplasmsGliomaNeurosurgical ProceduresPreoperative CareHumansNeurosurgeonsSurveys and QuestionnairesDecision-makingEloquenceFunctional areasGliomaNeuro-oncologyNeurosurgerySurvey

Identifiers

PMID40397319
PMCPMC12367934

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.