ArticleBulletin of mathematical biology2025
Inference of Pairwise Interactions from Strain Frequency Data Across Settings and Context-Dependent Mutual Invasibilities.
Article in Bulletin of mathematical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We propose a method to estimate pairwise strain interactions from population-level frequencies across different endemic settings. We apply the framework of replicator dynamics, derived from a multi-strain SIS model with co-colonization, to extract from 5 datasets the fundamental backbone of strain interactions. In our replicator, each pairwise invasion fitness explicitly arises from local environmental context and trait variations between strains. We adopt the simplest formulation for multi-strain coexistence, where context is encoded in basic reproduction number
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