Evidence map›Paper›PMID 40397170›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Fanconi anemia patients with head and neck squamous cell carcinoma - a multi-center study.

Nir Tsur, Anner Moskovitz, Yehuda Zadik, Ehud Even-Or, Narin Nard Carmel Neiderman, Elchanan Zloczower, Omry Frig, Orna Steinberg-Shemer, Hannah Tamary, Noga Kurman and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nir TsurDepartment of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Israel. nirtsur19@gmail.com.ORCID http://orcid.org/0000-0002-2178-8971
Anner MoskovitzFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Yehuda ZadikDepartment of Oral Medicine and Saligman Clinics, Faculty of Dental Medicine, Hebrew University of Jerusalem and Hadassah Medical Center, Jerusalem, Israel.
Ehud Even-OrDepartment of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah-Hebrew University Medical Center, and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Narin Nard Carmel NeidermanDepartment of Otolaryngology, Head & Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
Elchanan ZloczowerDepartment of Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Omry FrigDepartment of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Israel.
Orna Steinberg-ShemerFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Hannah TamaryFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Noga KurmanDepartment of Radiotherapy, Davidoff Cancer Center, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
Inna OspovatOncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Eyal YosefofDepartment of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the presentation, treatment, and outcomes of head and neck squamous cell carcinoma (HNSCC) in patients with Fanconi anemia (FA), a rare genetic disorder characterized by increased cancer risk and treatment complications.

methodsWe conducted a retrospective cohort study of 11 FA patients diagnosed with HNSCC across five XXX medical centers from 2014 to 2023. Data on patient demographics, tumor characteristics, treatment modalities, complications, recurrences, and survival outcomes were analyzed using descriptive and survival statistics.

resultsFA patients developed HNSCC at a median age of 31.5 years, primarily in the oral cavity. Surgical treatment was the primary treatment modality; however adjunct radiotherapy resulted in severe complications, such as high-grade mucositis in 75% of cases. Median overall survival was 28.7 months, with 36.4% of patients succumbing within 12 months of diagnosis. Recurrences were noted in three patients, split equally between local and distant sites, and 36% developed secondary malignancies up to 17 years post-initial diagnosis.

conclusionsHNSCC in FA patients presents distinct challenges, including a younger onset age, high rates of severe treatment complications, and poor survival outcomes. Tailoring treatment strategies to minimize radiotherapy exposure and implementing rigorous, long-term surveillance for second malignancies are essential for managing these high-risk patients. LEVEL OF EVIDENCE: Level IV.

Indexed as

Fanconi AnemiaHead and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckAdolescentAdultAgedFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesSurvival RateYoung AdultChemoradiation therapyFanconi anemiaHNSCCOral cancerSurvival

Identifiers

PMID40397170
PMCPMC12423260

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.