Evidence map›Paper›PMID 40397157›Full record

ArticleBioprocess and biosystems engineering2025

Investigation of antioxidant, antibacterial, anticancer and wound healing properties of eco-friendly synthesized copper oxide nanoparticles from Plumeria rubra leaf extract.

Annapoorani Angusamy, Subramanian Palanisamy, Sangeetha Ravi, Manikandan Kumaresan, Sonaimuthu Mohandoss, SangGuan You, Manikandan Ramar

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Article in Bioprocess and biosystems engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Annapoorani Angusamy *Department of Biotechnology, Faculty of Biomedical Sciences & Technology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, 600116, India.
Subramanian Palanisamy *East Coast Life Sciences Institute, Gangneung-Wonju National University, 120, Gangneung, Gangwon, 25457, Republic of Korea.
Sangeetha RaviDepartment of Zoology, University of Madras, Guindy campus, Chennai, 600025, India.
Manikandan KumaresanDepartment of Zoology, University of Madras, Guindy campus, Chennai, 600025, India.
Sonaimuthu Mohandoss *School of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
SangGuan YouEast Coast Life Sciences Institute, Gangneung-Wonju National University, 120, Gangneung, Gangwon, 25457, Republic of Korea.
Manikandan RamarDepartment of Zoology, University of Madras, Guindy campus, Chennai, 600025, India. manikandanramar@yahoo.co.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plants serve as a rich source of bioactive agents and coupling them with carriers using nanotechnology has recently become an effective therapeutic approach in pharmacognosy. Metal oxides, especially copper oxide (CuO), have been employed in synthesizing nanoparticles due to their efficient reducing properties. The purpose of this work was to examine the physicochemical, antioxidant, antibacterial, anticancer, and wound healing abilities of copper oxide nanoparticles (CuONPs) synthesized using Plumeria rubra leaf extract. FTIR, XRD, FESEM, EDX, AFM, and UV-vis spectroscopy were used to confirm the formation of CuONPs, and the results showed that they were spherical in shape and 35 nm in size. DPPH and nitric oxide antioxidant assays revealed that they possess effective free radical scavenging ability. CuONPs showed bactericidal activity against human pathogenic bacteria. The anticancer effect of CuONPs was assessed on the Neuro-2a (N2a) neuroblastoma cells. Both P. rubra leaf extract and CuONPs exhibited dose-dependent cytotoxicity with morphological distortions and apoptosis, along with a loss of membrane integrity. In vivo analysis of CuONPs for their wound healing ability in Wistar albino rats showed a better wound closure percentage compared to that of the control animals. Based on our findings, CuONPs may be applied as a potential therapeutic agent in developing treatments for a spectrum of various diseases.

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsAntioxidantsCopperMetal NanoparticlesPlant ExtractsPlant LeavesWound HealingAnimalsCell Line, TumorGreen Chemistry TechnologyHumansMaleMiceRatsRats, WistarAnti-Bacterial AgentsAntineoplastic AgentsAntioxidantsCoppercuprous oxidePlant ExtractsAntibacterialAnticancerCopper oxide nanoparticlesGreen synthesisWound healing

Identifiers

PMID40397157

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.