Evidence map›Paper›PMID 40397146›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2025

Identifying and validating prognostic parameters to predict curve progression in adolescents with idiopathic scoliosis.

Mahdieh Khodaei, Eric C Parent, Lawrence H Le, Kyle Stampe, Sarah Southon Hryniuk, Edmond Lou

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mahdieh KhodaeiUniversity of Alberta, Edmonton, Canada.
Eric C ParentUniversity of Alberta, Edmonton, Canada.
Lawrence H LeUniversity of Alberta, Edmonton, Canada.
Kyle StampeUniversity of Alberta, Edmonton, Canada.
Sarah Southon HryniukAlberta Health Services, Edmonton, Canada.
Edmond LouUniversity of Alberta, Edmonton, Canada. elou@ualberta.ca.

Funding

Scoliosis Research Society RES0038364
6 · The paper itself

Abstract

purposeThis study aimed to identify and validate prognostic factors to predict scoliosis progression.

methodsOne hundred sixty-two girls, aged 13.5 ± 1.7 years old, diagnosed with idiopathic scoliosis were recruited. One hundred were used for model development, and 62 for testing, in which the number of progression cases was 25 and 11, respectively. All participants were scanned by an ultrasound (US) system for two consecutive visits (baseline and follow-up). The baseline parameters included (a) demographic: age, body mass index (BMI), and menarche status; (b) radiographic: X-ray Cobb angle, number-of-curve (NOC), and Risser sign; (c) ultrasonic: US Cobb, maximum axial vertebral rotation (AVR), Cobb angle at the plane of maximum curvature (PMC), kyphotic angle (KA) and reflection coefficient (RC) index. For the follow-up visit, only the US Cobb was recorded. The demographic and X-ray parameters were extracted from the scoliosis clinical records. The US parameters were measured by trained raters with good measurement reliability. The prediction model was developed using logistic regression analysis.

resultsThe final predictors were US Cobb change, RC index, and NOC, and the probability of curve progression risk was Log (p/1-p) = -1.40 + 0.28(US Cobb change)-39.45(RC) + 1.36 (NOC). The model achieved sensitivity, specificity, and accuracy of 90% on the 62 test dataset, which was much better than using US Cobb change only.

conclusionsThe results indicated that participants with lower RC (weaker bone, RC ≤ 0.06), larger US Cobb change (≥ 5°), and multiple curvatures (NOC > 1) were at a higher risk of curve progression. A large study including more progression cases is needed for further validation.

Indexed as

Disease ProgressionScoliosisAdolescentChildFemaleHumansPrognosisRadiographyReproducibility of ResultsUltrasonographyCobb changePrediction modelReflection coefficientScoliosisUltrasoundValidation

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.