Evidence map›Paper›PMID 40397143›Full record

ArticleParasitology research2025

Association of neurobiological and immune serum biomarkers with Toxoplasma gondii infection in patients with schizophrenia.

Olga Abramova, Yana Zorkina, Dmitry Goncharov, Evgenia Abbazova, Marina Baranets, Alexander Berdalin, Valeriya Ushakova, Valeria Zakurazhnaya, Irina Morozova, Alexandra Ochneva and 4 more

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Article in Parasitology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Olga AbramovaMental-Health Clinic No. 1 Named After N.A. Alexeev of Moscow Healthcare Department, Zagorodnoe Highway 2, 115191, Moscow, Russia. abramova1128@gmail.com.ORCID http://orcid.org/0000-0001-8793-1833
Yana ZorkinaMental-Health Clinic No. 1 Named After N.A. Alexeev of Moscow Healthcare Department, Zagorodnoe Highway 2, 115191, Moscow, Russia.
Dmitry Goncharov"National Research Center for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya" of the Ministry of Health of the Russian Federation, Gamaleyi Street, 18, 123098, Moscow, Russia.
Evgenia Abbazova"National Research Center for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya" of the Ministry of Health of the Russian Federation, Gamaleyi Street, 18, 123098, Moscow, Russia.
Marina Baranets"National Research Center for Epidemiology and Microbiology Named After Honorary Academician N. F. Gamaleya" of the Ministry of Health of the Russian Federation, Gamaleyi Street, 18, 123098, Moscow, Russia.
Alexander BerdalinMental-Health Clinic No. 1 Named After N.A. Alexeev of Moscow Healthcare Department, Zagorodnoe Highway 2, 115191, Moscow, Russia.
Valeriya UshakovaMental-Health Clinic No. 1 Named After N.A. Alexeev of Moscow Healthcare Department, Zagorodnoe Highway 2, 115191, Moscow, Russia.
Valeria ZakurazhnayaMental-Health Clinic No. 1 Named After N.A. Alexeev of Moscow Healthcare Department, Zagorodnoe Highway 2, 115191, Moscow, Russia.
Irina MorozovaMental-Health Clinic No. 1 Named After N.A. Alexeev of Moscow Healthcare Department, Zagorodnoe Highway 2, 115191, Moscow, Russia.
Alexandra OchnevaMental-Health Clinic No. 1 Named After N.A. Alexeev of Moscow Healthcare Department, Zagorodnoe Highway 2, 115191, Moscow, Russia.
Konstantin PavlovMental-Health Clinic No. 1 Named After N.A. Alexeev of Moscow Healthcare Department, Zagorodnoe Highway 2, 115191, Moscow, Russia.
Denis AndreyukMental-Health Clinic No. 1 Named After N.A. Alexeev of Moscow Healthcare Department, Zagorodnoe Highway 2, 115191, Moscow, Russia.
Georgy KostyukMental-Health Clinic No. 1 Named After N.A. Alexeev of Moscow Healthcare Department, Zagorodnoe Highway 2, 115191, Moscow, Russia.
Anna MorozovaMental-Health Clinic No. 1 Named After N.A. Alexeev of Moscow Healthcare Department, Zagorodnoe Highway 2, 115191, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some studies suggest that Toxoplasma gondii infection may increase the risk of developing schizophrenia. Determining changes in blood biomarker concentrations may provide new insights into the underlying mechanisms associated with Toxoplasma gondii infection in schizophrenia. The aim of the study was to evaluate the concentrations of several serum neurobiological and immune parameters and to identify changes in their concentrations that could potentially be indicators of psychopathologic changes in infection. The concentration of biomarkers was determined in serum from patients with schizophrenia (uninfected n = 50, infected n = 30) and from mentally healthy volunteers (uninfected n = 51, infected n = 29) using multiplex analysis. A number of psychometric scales have been applied to assess the cognitive functioning. No significant associations were between schizophrenia and Toxoplasma gondii infection (p = 0.54; OR = 1.18; 95% CI = 0.69-2.01). However, infected patients with schizophrenia had more severe cognitive impairment compared to uninfected schizophrenia patients (PDQ-20). The group of biomarkers has been identified whose concentration changes were observed only between Toxoplasma gondii-infected healthy individuals and individuals with schizophrenia (neurobiological indicators KLK6, UCHL1, Amyloid beta 1-42 and neurogranin; anti-inflammatory cytokine IL-10; chemokines IL-8 and MIP-1 beta), but not between uninfected groups. The hypothesis was proposed that it is possible to use these indices as indicators of the development of schizophrenic psychopathology in Toxoplasma gondii infection. The associations of blood biomarker concentrations with IgA and IgM antibody levels (chemokine RANTES) and with schizophrenia symptoms (hormone-like messenger KLK6; chemokines IP-10 and GRO alpha) were found. Toxoplasma gondii reactivation leads to a decrease in negative symptomatology and reduced FGF-21 levels in patients with schizophrenia, and increased CNTF and NGF beta levels compared to the latent form.

Indexed as

BiomarkersSchizophreniaToxoplasmosisAdultCytokinesFemaleHumansMaleMiddle AgedToxoplasmaYoung AdultBiomarkersCytokinesDiagnosisImmune biomarkersNeurobiological biomarkersSchizophreniaSerum biomarkersToxoplasma gondii

Identifiers

PMID40397143
PMCPMC12095432

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