Evidence map›Paper›PMID 40397128›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Associations between dementia symptoms and caregiver and relationship health: A prominent role for speech and language.

Robert W Levenson, Jennifer Merrilees, Maya L Henry, Nina F Dronkers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Language deficits across PET-based Braak stages of tau accumulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Robert W LevensonDepartment of Psychology, University of California, Berkeley, CA, USA.ORCID 0000-0002-2036-793X
Jennifer MerrileesUCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.ORCID 0000-0003-0907-0139
Maya L HenryDepartment of Speech, Language, and Hearing Sciences, University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-8745-6451
Nina F DronkersDepartment of Psychology, University of California, Berkeley, CA, USA.ORCID 0000-0003-4462-2963

Funding

Predicting Risk for Adverse Outcomes in Dementia CaregiversR01AG062639 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI Casey Leigh Brown, Robert Wayne Levenson · 2019 to 2026
$4.8M
Establishing Evidence-based Treatment for Speech and Language in Primary Progressive AphasiaR01DC016291 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI HENRY, MAYA · 2017 to 2021
$3.3M
Commercializing In-Home Supportive Technolgy for Dementia CaregiversSB1AG059458 · NIA · PEOPLE POWER COMPANY · PI WANG, GENE · 2021 to 2022
$3.2M
Burden, Depression, and Health in Dementia Caregivers: The Role of EmotionR01AG041762 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI LEVENSON, ROBERT WAYNE · 2012 to 2016
$2.8M
Neural Mechanisms of Song vs Speech Production: Insights from Aphasia and Intracranial RecordingR21DC021042 · NIDCD · UNIVERSITY OF CALIFORNIA BERKELEY · PI DRONKERS, NINA F. · 2023 to 2024
$417k
Establishing Evidence-based Treatment for Speech and Language in Primary Progressive AphasiaR56DC016291 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI HENRY, MAYA · 2023 to 2023
$97k
NIA NIH HHS R01 AG041762NIA NIH HHS R01 AG062639NIA NIH HHS SB1 AG059458NIDCD NIH HHS R01 DC016291NIDCD NIH HHS R21 DC021042NIDCD NIH HHS R56 DC016291
6 · The paper itself

Abstract

BackgroundDementia is a significant public health issue globally. People with dementia (PWD) exhibit symptoms in multiple domains (e.g., cognition, emotion, motor, speech/language) that can vary in their impact on the caregiver and the PWD-caregiver relationship.ObjectiveWe assessed the relative impact of various dementia symptoms on caregiver health and well-being and on the PWD-caregiver relationship using a broad sampling of PWD symptoms and caregiver/relationship outcome measures.MethodsData were analyzed from 54 primary caregivers of PWDs who completed seven questionnaires assessing caregiver health and well-being and PWD-caregiver relationship quality. An exploratory factor analysis of these questionnaires revealed two primary factors: (a) General Distress (anxiety, burden, depression, general health, loneliness), and (b) Relationship Quality (interpersonal closeness, relationship satisfaction). Caregivers also rated nine categories of PWD symptoms (memory, executive functions, speech/language, visual/spatial, motor, changes in behavior, sleep, medical/sensory, activities of daily living).ResultsGreater caregiver General Distress was associated with greater PWD speech/language and sleep symptoms. Lower caregiver Relationship Quality was associated (at trend,

Indexed as

CaregiversDementiaInterpersonal RelationsLanguageSpeechActivities of Daily LivingAgedAged, 80 and overFemaleHumansMaleMiddle AgedSurveys and QuestionnairesAlzheimer's diseasecaregiversdementialanguagespeech

Identifiers

PMID40397128
PMCPMC12231857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.